{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Wang W"],"funding":["NIAID NIH HHS"],"pubmed_abstract":["Antigenic assessments of SARS-CoV-2 variants inform decisions to update COVID-19 vaccines. Primary infection sera are often used for assessments, but such sera are rare due to population immunity from SARS-CoV-2 infections and COVID-19 vaccinations. Here, we show that neutralization titers and breadth of matched human and hamster pre-Omicron variant primary infection sera correlate well and generate similar antigenic maps. The hamster antigenic map shows modest antigenic drift among XBB sub-lineage variants, with JN.1 and BA.4/BA.5 variants within the XBB cluster, but with five to six-fold antigenic differences between these variants and XBB.1.5. Compared to sera following only ancestral or bivalent COVID-19 vaccinations, or with post-vaccination infections, XBB.1.5 booster sera had the br"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.04.05.588359"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11071293"],"repository":["biostudies-literature"],"pubmed_title":["Antigenic cartography using hamster sera identifies SARS-CoV-2 JN.1 evasion seen in human XBB.1.5 booster sera."],"pmcid":["PMC11071293"],"funding_grant_id":["Y01 AI005072","HHSN272201800013C"],"pubmed_authors":["Goguet E","Selvaraj P","Lusvarghi S","Katzelnick LC","Bhushan GL","Paz S","Conte MA","Epsi NJ","Agan B","Stauft CB","Mitre E","Bishop-Lilly KA","Holbrook MR","Vassell R","Burgess TH","Weiss CD","Fung CK","Richard SA","Wang W","Cong Y","Pollett SD","Subramanian R","Wang TT","Fries A"],"additional_accession":[]},"is_claimable":false,"name":"Antigenic cartography using hamster sera identifies SARS-CoV-2 JN.1 evasion seen in human XBB.1.5 booster sera.","description":"Antigenic assessments of SARS-CoV-2 variants inform decisions to update COVID-19 vaccines. Primary infection sera are often used for assessments, but such sera are rare due to population immunity from SARS-CoV-2 infections and COVID-19 vaccinations. Here, we show that neutralization titers and breadth of matched human and hamster pre-Omicron variant primary infection sera correlate well and generate similar antigenic maps. The hamster antigenic map shows modest antigenic drift among XBB sub-lineage variants, with JN.1 and BA.4/BA.5 variants within the XBB cluster, but with five to six-fold antigenic differences between these variants and XBB.1.5. Compared to sera following only ancestral or bivalent COVID-19 vaccinations, or with post-vaccination infections, XBB.1.5 booster sera had the br","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-07-01T03:14:35.727Z","creation":"2026-07-01T03:07:56.136Z"},"accession":"S-EPMC11071293","cross_references":{"pubmed":["38712124"],"doi":["10.1101/2024.04.05.588359"]}}