{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Strom NI"],"funding":["BLRD VA","NICHD NIH HHS","NCATS NIH HHS","NIDA NIH HHS","NCRR NIH HHS","NIA NIH HHS","NIMH NIH HHS","NHLBI NIH HHS","NIAAA NIH HHS","HSRD VA","CSRD VA","European Research Council","NHGRI NIH HHS","NINDS NIH HHS","NIGMS NIH HHS"],"pubmed_abstract":["Obsessive-compulsive disorder (OCD) affects ~1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identified 30 independent genome-wide significant loci. Gene-based approaches identified 249 potential effector genes for OCD, with 25 of these classified as the most likely causal candidates, including <i>WDR6</i>, <i>DALRD3</i>, <i>CTNND1</i> and multiple genes in the MHC region. We estimated that ~11,500 genetic variants explained 90% of OCD genetic heritability. OCD genetic risk was associated with excitatory neurons in the hippocampus and cortex, along with D1- and D2-type dopamine receptor-containing medium spiny neurons. OCD genetic risk was shared with 6"],"journal":["medRxiv : the preprint server for health sciences"],"pagination":["2024.03.13.24304161"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11071577"],"repository":["biostudies-literature"],"pubmed_title":["Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder."],"pmcid":["PMC11071577"],"funding_grant_id":["R01 MH079488","R01 MH079489","IK2 BX005058","R01 AA026364","R01 MH079487","RC2 GM092618","R56 MH120736","R01 MH059299","R01 MH113362","R01 MH124871","R01 NS102371","U10 AA008401","UL1 RR024975","R01 MH103657","K99 MH128540","S10 RR025141","T32 GM080178","R01 MH085321","R01 MH124679","R01 MH071507","R01 MH101493","R01 MH124851","R01 MH124873","UL1 TR002243","R01 DA054869","U01 HG004798","R21 MH109938","U01 HG006378","R01 MH093381","I01 CX001849","R01 MH058376","UL1 TR000445","R01 NS032830","834057","R01 MH079494","T32 GM008042","R01 NS105746","P50 GM115305","K23 MH066284","R01 MH110427","R01 MH050214","R01 HD074711","R01 MH114927","R56 AG068026","R01 MH105500","U19 HL065962","IP1 HX002375"],"pubmed_authors":["Palviainen T","Cavallini MC","Kaprio J","Martin NG","23andMe Inc.","Byrne EM","Soler Artigas M","Sealock JM","Sandin S","Grabe HJ","Haavik J","McArthur E","Hagen K","Fernandez TV","Milani L","Ruhrmann S","Andre C","Klawohn J","Levey D","Turiel M","Estivill X","Davis LK","Garner L","Krasnow JE","Ciullo V","Eapen V","Neale BM","Luykx JJ","Stein MB","Derks EM","Yu D","Ribases M","McLaughlin NC","Askland KD","Mattheisen M","Stewart SE","Mulhern M","Ramirez A","Landen M","Harrington K","Fyer AJ","Lange C","Rabionet R","Maher B","Hoffler KD","Rodriguez-Fontenla C","Alemany S","Goes FS","Verweij KJ","Berberich G","Zai G","Nordentoft M","Lindblad-Toh K","Geller DA","Andreassen OA","Vulink NN","Medland SE","Stranger BE","Macciardi F","Storch EA","Brennan BP","Cappi C","Wagner M","Greenberg BD","Kennedy J","Bosch R","Nestadt G","Mathews CA","Miguel EC","Thomas LF","McCracken JT","Halvorsen MW","Hougaard DM","Brentani H","Spalletta G","Hultman C","Hickie IB","Lai D","Nicolini H","Borte S","Reichenberg A","Ripke S","Kvale G","Buxbaum JD","Delorme R","Grados MA","Nissen JB","Reichborn-Kjennerud T","Pauls DL","Djurovic S","Vallada H","Kathmann N","Bulik CM","Strom NI","Lanzagorta N","Bey K","Le Hellard S","Cath D","Walitza S","Gaziano JM","Gerring ZF","Havdahl A","Bybjerg-Grauholm J","Lochner C","Richter MA","Guo W","Barlassina C","van Kirk N","Wendland JR","Alonso P","Samuels JF","Arnold PD","Sloofman LG","Riddle MA","Burton CL","Leboyer M","Scharf JM","Ousdal OT","Elias JA","Bloch MH","Posthuma D","Mataix-Cols D","Grunblatt E","Hansen BK","Meier S","Piras F","Krebs K","Fundin BT","Mors O","De Schipper EJ","Coleman JR","Camarena B","Camarena A","Pedersen NL","Bigdeli T","Nestadt PS","Casas M","Zhou H","Bucholz KK","Janecka M","Sandor P","Potluri S","Kelley K","Pato M","Grove J","Agrawal A","Black D","Cabana-Dominguez J","Hounie AG","Hucks D","Stein DJ","Walker CP","O'Connell KS","Osiecki L","Pato C","Zwart JA","Ask H","Galimberti M","Hveem K","Gelernter J","Crosby J","Falkenstein MJ","Banaj N","Wang Y","Rasmussen SA","Hanna GL","Cook EH","Sampaio AS","Bienvenu OJ","Breen G","Breen M","Carracedo A","Thorp JG","Mathes B","Nurmi EL","Schiele MA","Mortensen PB","Karlsson EK","Piacentini J","McGregor N","Abdellaoui A","Rauch S","Edenberg H","Smit DJ","Cullen BA","Grice DE","Knowles JA","Jenike E","Rosario MC","Borglum AD","Mahjani B","Yao Y","Werge T","Winsvold BS","Falkai P","Crowley JJ","Smit J","Tifft E","Ruck C","Denys D","Ramos-Quiroga JA","Gironda C","Domschke K","Backmann J","Pittenger C","Estonian Biobank","Veenstra-VanderWeele J","Rosenberg DR","Skogholt AH"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.","description":"Obsessive-compulsive disorder (OCD) affects ~1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identified 30 independent genome-wide significant loci. Gene-based approaches identified 249 potential effector genes for OCD, with 25 of these classified as the most likely causal candidates, including <i>WDR6</i>, <i>DALRD3</i>, <i>CTNND1</i> and multiple genes in the MHC region. We estimated that ~11,500 genetic variants explained 90% of OCD genetic heritability. OCD genetic risk was associated with excitatory neurons in the hippocampus and cortex, along with D1- and D2-type dopamine receptor-containing medium spiny neurons. OCD genetic risk was shared with 6","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-07-01T03:24:58.698Z","creation":"2026-07-01T03:12:36.075Z"},"accession":"S-EPMC11071577","cross_references":{"pubmed":["38712091"],"doi":["10.1101/2024.03.13.24304161"]}}