biostudies-literatureUnknownStrom NIBLRD VANICHD NIH HHSNCATS NIH HHSNIDA NIH HHSNCRR NIH HHSNIA NIH HHSNIMH NIH HHSNHLBI NIH HHSNIAAA NIH HHSHSRD VACSRD VAEuropean Research CouncilNHGRI NIH HHSNINDS NIH HHSNIGMS NIH HHSObsessive-compulsive disorder (OCD) affects ~1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identified 30 independent genome-wide significant loci. Gene-based approaches identified 249 potential effector genes for OCD, with 25 of these classified as the most likely causal candidates, including <i>WDR6</i>, <i>DALRD3</i>, <i>CTNND1</i> and multiple genes in the MHC region. We estimated that ~11,500 genetic variants explained 90% of OCD genetic heritability. OCD genetic risk was associated with excitatory neurons in the hippocampus and cortex, along with D1- and D2-type dopamine receptor-containing medium spiny neurons. OCD genetic risk was shared with 6medRxiv : the preprint server for health sciences2024.03.13.24304161https://www.ebi.ac.uk/biostudies/studies/S-EPMC11071577biostudies-literatureGenome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.PMC11071577R01 MH079488R01 MH079489IK2 BX005058R01 AA026364R01 MH079487RC2 GM092618R56 MH120736R01 MH059299R01 MH113362R01 MH124871R01 NS102371U10 AA008401UL1 RR024975R01 MH103657K99 MH128540S10 RR025141T32 GM080178R01 MH085321R01 MH124679R01 MH071507R01 MH101493R01 MH124851R01 MH124873UL1 TR002243R01 DA054869U01 HG004798R21 MH109938U01 HG006378R01 MH093381I01 CX001849R01 MH058376UL1 TR000445R01 NS032830834057R01 MH079494T32 GM008042R01 NS105746P50 GM115305K23 MH066284R01 MH110427R01 MH050214R01 HD074711R01 MH114927R56 AG068026R01 MH105500U19 HL065962IP1 HX002375Palviainen TCavallini MCKaprio JMartin NG23andMe Inc.Byrne EMSoler Artigas MSealock JMSandin SGrabe HJHaavik JMcArthur EHagen KFernandez TVMilani LRuhrmann SAndre CKlawohn JLevey DTuriel MEstivill XDavis LKGarner LKrasnow JECiullo VEapen VNeale BMLuykx JJStein MBDerks EMYu DRibases MMcLaughlin NCAskland KDMattheisen MStewart SEMulhern MRamirez ALanden MHarrington KFyer AJLange CRabionet RMaher BHoffler KDRodriguez-Fontenla CAlemany SGoes FSVerweij KJBerberich GZai GNordentoft MLindblad-Toh KGeller DAAndreassen OAVulink NNMedland SEStranger BEMacciardi FStorch EABrennan BPCappi CWagner MGreenberg BDKennedy JBosch RNestadt GMathews CAMiguel ECThomas LFMcCracken JTHalvorsen MWHougaard DMBrentani HSpalletta GHultman CHickie IBLai DNicolini HBorte SReichenberg ARipke SKvale GBuxbaum JDDelorme RGrados MANissen JBReichborn-Kjennerud TPauls DLDjurovic SVallada HKathmann NBulik CMStrom NILanzagorta NBey KLe Hellard SCath DWalitza SGaziano JMGerring ZFHavdahl ABybjerg-Grauholm JLochner CRichter MAGuo WBarlassina Cvan Kirk NWendland JRAlonso PSamuels JFArnold PDSloofman LGRiddle MABurton CLLeboyer MScharf JMOusdal OTElias JABloch MHPosthuma DMataix-Cols DGrunblatt EHansen BKMeier SPiras FKrebs KFundin BTMors ODe Schipper EJColeman JRCamarena BCamarena APedersen NLBigdeli TNestadt PSCasas MZhou HBucholz KKJanecka MSandor PPotluri SKelley KPato MGrove JAgrawal ABlack DCabana-Dominguez JHounie AGHucks DStein DJWalker CPO'Connell KSOsiecki LPato CZwart JAAsk HGalimberti MHveem KGelernter JCrosby JFalkenstein MJBanaj NWang YRasmussen SAHanna GLCook EHSampaio ASBienvenu OJBreen GBreen MCarracedo AThorp JGMathes BNurmi ELSchiele MAMortensen PBKarlsson EKPiacentini JMcGregor NAbdellaoui ARauch SEdenberg HSmit DJCullen BAGrice DEKnowles JAJenike ERosario MCBorglum ADMahjani BYao YWerge TWinsvold BSFalkai PCrowley JJSmit JTifft ERuck CDenys DRamos-Quiroga JAGironda CDomschke KBackmann JPittenger CEstonian BiobankVeenstra-VanderWeele JRosenberg DRSkogholt AHfalseGenome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.Obsessive-compulsive disorder (OCD) affects ~1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identified 30 independent genome-wide significant loci. Gene-based approaches identified 249 potential effector genes for OCD, with 25 of these classified as the most likely causal candidates, including <i>WDR6</i>, <i>DALRD3</i>, <i>CTNND1</i> and multiple genes in the MHC region. We estimated that ~11,500 genetic variants explained 90% of OCD genetic heritability. OCD genetic risk was associated with excitatory neurons in the hippocampus and cortex, along with D1- and D2-type dopamine receptor-containing medium spiny neurons. OCD genetic risk was shared with 62025-01-01T00:00:00Z2025 Apr2026-07-01T03:24:58.698Z2026-07-01T03:12:36.075ZS-EPMC110715773871209110.1101/2024.03.13.24304161