{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liao Z"],"funding":["Innovative Research Group Project of the National Natural Science Foundation of China","Ministry of Science and Technology of the People's Republic of China","Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences and Peking Union Medical College","Ministry of Science and Technology of the People's Republic of China","Cultivating Plan Program for the Leader in Science and Technology of Yunnan Province","Applied Basic Research Foundation of Yunnan Province"],"pagination":["35"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11071750"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["79(1)"],"pubmed_abstract":["Multiple representatives of eulipotyphlan mammals such as shrews have oral venom systems. Venom facilitates shrews to hunt and/or hoard preys. However, little is known about their venom composition, and especially the mechanism to hoard prey in comatose states for meeting their extremely high metabolic rates. A toxin (BQTX) was identified from venomous submaxillary glands of the shrew Blarinella quadraticauda. BQTX is specifically distributed and highly concentrated (~ 1% total protein) in the organs. BQTX shares structural and functional similarities to toxins from snakes, wasps and snails, suggesting an evolutional relevancy of venoms from mammalians and non-mammalians. By potentiating thrombin and factor-XIIa and inhibiting plasmin, BQTX induces acute hypertension, blood coagulation and"],"journal":["Cellular and molecular life sciences : CMLS"],"pubmed_title":["Shrew's venom quickly causes circulation disorder, analgesia and hypokinesia."],"pmcid":["PMC11071750"],"funding_grant_id":["2019FB127","XDB31000000","32070443","81770464","2019ZF003","KFJ-STS-SCYD-304","2019FA006","32100907","2018YFA0801403","31930015","202003AD150008"],"pubmed_authors":["Liao Z","He K","Li Q","Duan Z","Lv L","Kamau PM","Chen Z","Zhang Z","Jiang X","He X","Chen W","Lai R","Rong M","Tang X","Lv Q"],"additional_accession":[]},"is_claimable":false,"name":"Shrew's venom quickly causes circulation disorder, analgesia and hypokinesia.","description":"Multiple representatives of eulipotyphlan mammals such as shrews have oral venom systems. Venom facilitates shrews to hunt and/or hoard preys. However, little is known about their venom composition, and especially the mechanism to hoard prey in comatose states for meeting their extremely high metabolic rates. A toxin (BQTX) was identified from venomous submaxillary glands of the shrew Blarinella quadraticauda. BQTX is specifically distributed and highly concentrated (~ 1% total protein) in the organs. BQTX shares structural and functional similarities to toxins from snakes, wasps and snails, suggesting an evolutional relevancy of venoms from mammalians and non-mammalians. By potentiating thrombin and factor-XIIa and inhibiting plasmin, BQTX induces acute hypertension, blood coagulation and","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2026-06-02T08:38:38.021Z","creation":"2026-05-25T03:06:45.022Z"},"accession":"S-EPMC11071750","cross_references":{"pubmed":["34989866"],"doi":["10.1007/s00018-021-04116-x"]}}