{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chetverina D"],"funding":["Russian Science Foundation"],"pagination":["353"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11072172"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["79(7)"],"pubmed_abstract":["The Polycomb group (PcG) and Trithorax group (TrxG) proteins are key epigenetic regulators controlling the silenced and active states of genes in multicellular organisms, respectively. In Drosophila, PcG/TrxG proteins are recruited to the chromatin via binding to specific DNA sequences termed polycomb response elements (PREs). While precise mechanisms of the PcG/TrxG protein recruitment remain unknown, the important role is suggested to belong to sequence-specific DNA-binding factors. At the same time, it was demonstrated that the PRE DNA-binding proteins are not exclusively localized to PREs but can bind other DNA regulatory elements, including enhancers, promoters, and boundaries. To gain an insight into the PRE DNA-binding protein regulatory network, here, using ChIP-seq and immuno-affi"],"journal":["Cellular and molecular life sciences : CMLS"],"pubmed_title":["Comparative interactome analysis of the PRE DNA-binding factors: purification of the Combgap-, Zeste-, Psq-, and Adf1-associated proteins."],"pmcid":["PMC11072172"],"funding_grant_id":["18-74-10091"],"pubmed_authors":["Mazina MY","Fab LV","Mogila V","Vorobyeva NE","Georgiev P","Chetverina D","Ziganshin RH","Golovnina A","Erokhin M","Lomaev D"],"additional_accession":[]},"is_claimable":false,"name":"Comparative interactome analysis of the PRE DNA-binding factors: purification of the Combgap-, Zeste-, Psq-, and Adf1-associated proteins.","description":"The Polycomb group (PcG) and Trithorax group (TrxG) proteins are key epigenetic regulators controlling the silenced and active states of genes in multicellular organisms, respectively. In Drosophila, PcG/TrxG proteins are recruited to the chromatin via binding to specific DNA sequences termed polycomb response elements (PREs). While precise mechanisms of the PcG/TrxG protein recruitment remain unknown, the important role is suggested to belong to sequence-specific DNA-binding factors. At the same time, it was demonstrated that the PRE DNA-binding proteins are not exclusively localized to PREs but can bind other DNA regulatory elements, including enhancers, promoters, and boundaries. To gain an insight into the PRE DNA-binding protein regulatory network, here, using ChIP-seq and immuno-affi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2026-06-01T23:42:45.429Z","creation":"2025-09-01T03:08:25.406Z"},"accession":"S-EPMC11072172","cross_references":{"pubmed":["35676368"],"doi":["10.1007/s00018-022-04383-2"]}}