biostudies-literatureDe Berdt PFonds De La Recherche Scientifique - FNRSInternational Foundation for Research in Paraplegia252https://www.ebi.ac.uk/biostudies/studies/S-EPMC11072347biostudies-literatureUnknown79(5)Traumatic spinal cord injury is an overwhelming condition that strongly and suddenly impacts the patient's life and her/his entourage. There are currently no predictable treatments to repair the spinal cord, while many strategies are proposed and evaluated by researchers throughout the world. One of the most promising avenues is the transplantation of stem cells, although its therapeutic efficiency is limited by several factors, among which cell survival at the lesion site. In our previous study, we showed that the implantation of a human dental apical papilla, residence of stem cells of the apical papilla (SCAP), supported functional recovery in a rat model of spinal cord hemisection. In this study, we employed protein multiplex, immunohistochemistry, cytokine arrays, RT- qPCR, and RNAseqCellular and molecular life sciences : CMLSThe human dental apical papilla promotes spinal cord repair through a paracrine mechanism.PMC11072347P155des Rieux ADe Berdt PVanvarenberg KPaquot AGratpain VBouzin CBearzatto BUcakar BLoriot AMuccioli GGPayen VGatto LDiogenes AfalseThe human dental apical papilla promotes spinal cord repair through a paracrine mechanism.Traumatic spinal cord injury is an overwhelming condition that strongly and suddenly impacts the patient's life and her/his entourage. There are currently no predictable treatments to repair the spinal cord, while many strategies are proposed and evaluated by researchers throughout the world. One of the most promising avenues is the transplantation of stem cells, although its therapeutic efficiency is limited by several factors, among which cell survival at the lesion site. In our previous study, we showed that the implantation of a human dental apical papilla, residence of stem cells of the apical papilla (SCAP), supported functional recovery in a rat model of spinal cord hemisection. In this study, we employed protein multiplex, immunohistochemistry, cytokine arrays, RT- qPCR, and RNAseq2022-01-01T00:00:00Z2022 Apr2026-06-01T05:26:08.666Z2026-04-08T09:35:41.027ZS-EPMC110723473544598410.1007/s00018-022-04210-8