{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wei M"],"funding":["National Natural Science Foundation of China"],"pagination":["472"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11073046"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["79(9)"],"pubmed_abstract":["Cholesterol biosynthesis plays a critical role in rapidly proliferating tumor cells. X-box binding protein 1 (XBP1), which was first characterized as a basic leucine zipper-type transcription factor, exists in an unspliced (XBP1-u) and spliced (XBP1-s) form. Recent studies showed that unspliced XBP1 (XBP1-u) has unique biological functions independent from XBP1-s and could promote tumorigenesis; however, whether it is involved in tumor metabolic reprogramming remains unknown. Herein, we found that XBP1-u promotes tumor growth by enhancing cholesterol biosynthesis in hepatocellular carcinoma (HCC) cells. Specifically, XBP1-u colocalizes with sterol regulatory element-binding protein 2 (SREBP2) and inhibits its ubiquitination/proteasomal degradation. The ensuing stabilization of SREBP2 activ"],"journal":["Cellular and molecular life sciences : CMLS"],"pubmed_title":["Unspliced XBP1 contributes to cholesterol biosynthesis and tumorigenesis by stabilizing SREBP2 in hepatocellular carcinoma."],"pmcid":["PMC11073046"],"funding_grant_id":["82173029","81872273","32070715","31871367"],"pubmed_authors":["Wei M","Huang C","Li Y","Wu S","Kasim V","Nurjanah U","Herkilini A","Miyagishi M"],"additional_accession":[]},"is_claimable":false,"name":"Unspliced XBP1 contributes to cholesterol biosynthesis and tumorigenesis by stabilizing SREBP2 in hepatocellular carcinoma.","description":"Cholesterol biosynthesis plays a critical role in rapidly proliferating tumor cells. X-box binding protein 1 (XBP1), which was first characterized as a basic leucine zipper-type transcription factor, exists in an unspliced (XBP1-u) and spliced (XBP1-s) form. Recent studies showed that unspliced XBP1 (XBP1-u) has unique biological functions independent from XBP1-s and could promote tumorigenesis; however, whether it is involved in tumor metabolic reprogramming remains unknown. Herein, we found that XBP1-u promotes tumor growth by enhancing cholesterol biosynthesis in hepatocellular carcinoma (HCC) cells. Specifically, XBP1-u colocalizes with sterol regulatory element-binding protein 2 (SREBP2) and inhibits its ubiquitination/proteasomal degradation. The ensuing stabilization of SREBP2 activ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2026-06-02T06:15:03.624Z","creation":"2026-04-15T03:14:56.369Z"},"accession":"S-EPMC11073046","cross_references":{"pubmed":["35933495"],"doi":["10.1007/s00018-022-04504-x"]}}