{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Melissari MT"],"funding":["Fondation Sante","Stavros Niarchos Foundation","European Research Council","Hellenic Foundation for Research and Innovation","European Crohn&apos;s and Colitis Organisation"],"pagination":["1"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11073078"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["79(1)"],"pubmed_abstract":["Intestinal mesenchymal cells encompass multiple subsets, whose origins, functions, and pathophysiological importance are still not clear. Here, we used the Col6a1<sup>Cre</sup> mouse, which targets distinct fibroblast subsets and perivascular cells that can be further distinguished by the combination of the CD201, PDGFRα and αSMA markers. Developmental studies revealed that the Col6a1<sup>Cre</sup> mouse also targets mesenchymal aggregates that are crucial for intestinal morphogenesis and patterning, suggesting an ontogenic relationship between them and homeostatic PDGFRα<sup>hi</sup> telocytes. Cell depletion experiments in adulthood showed that Col6a1<sup>+</sup>/CD201<sup>+</sup> mesenchymal cells regulate homeostatic enteroendocrine cell differentiation and epithelial proliferation. Du"],"journal":["Cellular and molecular life sciences : CMLS"],"pubmed_title":["Col6a1&lt;sup&gt;+&lt;/sup&gt;/CD201&lt;sup&gt;+&lt;/sup&gt; mesenchymal cells regulate intestinal morphogenesis and homeostasis."],"pmcid":["PMC11073078"],"funding_grant_id":["1687","340217"],"pubmed_authors":["Henriques A","Tzaferis C","Melissari MT","Koliaraki V","Chalkidi N","Prados A","Sarris ME","Grammenoudi S","Mavroeidi D","Chouvardas P","Kollias G"],"additional_accession":[]},"is_claimable":false,"name":"Col6a1&lt;sup&gt;+&lt;/sup&gt;/CD201&lt;sup&gt;+&lt;/sup&gt; mesenchymal cells regulate intestinal morphogenesis and homeostasis.","description":"Intestinal mesenchymal cells encompass multiple subsets, whose origins, functions, and pathophysiological importance are still not clear. Here, we used the Col6a1<sup>Cre</sup> mouse, which targets distinct fibroblast subsets and perivascular cells that can be further distinguished by the combination of the CD201, PDGFRα and αSMA markers. Developmental studies revealed that the Col6a1<sup>Cre</sup> mouse also targets mesenchymal aggregates that are crucial for intestinal morphogenesis and patterning, suggesting an ontogenic relationship between them and homeostatic PDGFRα<sup>hi</sup> telocytes. Cell depletion experiments in adulthood showed that Col6a1<sup>+</sup>/CD201<sup>+</sup> mesenchymal cells regulate homeostatic enteroendocrine cell differentiation and epithelial proliferation. Du","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2026-06-01T23:42:52.679Z","creation":"2026-05-23T03:08:22.75Z"},"accession":"S-EPMC11073078","cross_references":{"pubmed":["34910257"],"doi":["10.1007/s00018-021-04071-7"]}}