{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Srivastava K"],"funding":["Intramural NIH HHS"],"pagination":["189-197"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11073622"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(3)"],"pubmed_abstract":["<h4>Background</h4>Among 710 RHD alleles, 3 alleles have been shown to express CcEe antigens and, among 67 hybrid alleles of the RHD gene, 2 alleles have evolved to include RHCE exons 4-9. No breakpoint region had been described for such RHD-CE(4-9)-D hybrid alleles. In the Kidd blood group system, the JK*02N.01 null allele is found with high prevalence in the Polynesian population. We investigated a self-identified Pacific Islander with discrepant serologic and molecular results for his C and Jk<sup>b</sup> antigens. Another 8 samples with genotype-phenotype discrepancies in the Kidd blood group system were assessed.<h4>Materials and methods</h4>A combination of published molecular methods and commercial kits were applied to analyze the RHD, RHCE, and SLC14A1 gene sequences, as were hemag"],"journal":["Blood transfusion = Trasfusione del sangue"],"pubmed_title":["Breakpoint regions of an RHD-CE(4-9)-D allele and a rare JK allele in a Pacific Islander individual."],"pmcid":["PMC11073622"],"funding_grant_id":["ZIC CL002128"],"pubmed_authors":["Bueno MU","Flegel WA","Srivastava K"],"additional_accession":[]},"is_claimable":false,"name":"Breakpoint regions of an RHD-CE(4-9)-D allele and a rare JK allele in a Pacific Islander individual.","description":"<h4>Background</h4>Among 710 RHD alleles, 3 alleles have been shown to express CcEe antigens and, among 67 hybrid alleles of the RHD gene, 2 alleles have evolved to include RHCE exons 4-9. No breakpoint region had been described for such RHD-CE(4-9)-D hybrid alleles. In the Kidd blood group system, the JK*02N.01 null allele is found with high prevalence in the Polynesian population. We investigated a self-identified Pacific Islander with discrepant serologic and molecular results for his C and Jk<sup>b</sup> antigens. Another 8 samples with genotype-phenotype discrepancies in the Kidd blood group system were assessed.<h4>Materials and methods</h4>A combination of published molecular methods and commercial kits were applied to analyze the RHD, RHCE, and SLC14A1 gene sequences, as were hemag","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-01T17:26:11.952Z","creation":"2025-08-16T03:06:26.703Z"},"accession":"S-EPMC11073622","cross_references":{"pubmed":["37677094"],"doi":["10.2450/BloodTransfus.534"]}}