{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(1)"],"submitter":["Geedkar D"],"pubmed_abstract":["The present work elicits a novel approach to combating COVID-19 by synthesizing a series of azo-anchored 3,4-dihydroimidazo[4,5-b]indole derivatives. The envisaged methodology involves the L-proline-catalyzed condensation of para-amino-functionalized azo benzene, indoline-2,3-dione, and ammonium acetate precursors with pertinent aryl aldehyde derivatives under ultrasonic conditions. The structures of synthesized compounds were corroborated through FT-IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, and mass analysis data. Molecular docking studies assessed the inhibitory potential of these compounds against the main protease (M<sup>pro</sup>) of SARS-CoV-2. Remarkably, in silico investigations revealed significant inhibitory action surpassing standard drugs such as Remdesivir, Paxlovid, Molnupir"],"journal":["Scientific reports"],"pagination":["10419"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11074333"],"repository":["biostudies-literature"],"pubmed_title":["Synthesis and in silico inhibitory action studies of azo-anchored imidazo[4,5-b]indole scaffolds against the COVID-19 main protease (M<sup>pro</sup>)."],"pmcid":["PMC11074333"],"pubmed_authors":["Sharma P","Kumar A","Geedkar D"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis and in silico inhibitory action studies of azo-anchored imidazo[4,5-b]indole scaffolds against the COVID-19 main protease (M<sup>pro</sup>).","description":"The present work elicits a novel approach to combating COVID-19 by synthesizing a series of azo-anchored 3,4-dihydroimidazo[4,5-b]indole derivatives. The envisaged methodology involves the L-proline-catalyzed condensation of para-amino-functionalized azo benzene, indoline-2,3-dione, and ammonium acetate precursors with pertinent aryl aldehyde derivatives under ultrasonic conditions. The structures of synthesized compounds were corroborated through FT-IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, and mass analysis data. Molecular docking studies assessed the inhibitory potential of these compounds against the main protease (M<sup>pro</sup>) of SARS-CoV-2. Remarkably, in silico investigations revealed significant inhibitory action surpassing standard drugs such as Remdesivir, Paxlovid, Molnupir","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-01T08:04:18.415Z","creation":"2026-04-08T10:48:52.82Z"},"accession":"S-EPMC11074333","cross_references":{"pubmed":["38710746"],"doi":["10.1038/s41598-024-57795-4"]}}