biostudies-literatureMeng YThis work was financially supported by Special Funding Projects for Local Science and Technology Development Guided by the Central CommitteeThis work was financially supported by Hainan Province key research and development projectThis work was financially supported by China Agriculture Research System of MOF and MARAThis work was financially supported by Academician Innovation Platform Project of Hainan ProvinceThis work was financially supported by Hainan Innovation Center for Academician of Zhang Yong.44https://www.ebi.ac.uk/biostudies/studies/S-EPMC11075337biostudies-literatureUnknown25(1)<h4>Background</h4>China has thousands years of goat breeding and abundant goat genetic resources. Additionally, the Hainan black goat is one of the high-quality local goat breeds in China. In order to conserve the germplasm resources of the Hainan black goat, facilitate its genetic improvement and further protect the genetic diversity of goats, it is urgent to develop a single nucleotide polymorphism (SNP) chip for Hainan black goat.<h4>Results</h4>In this study, we aimed to design a 10K liquid chip for Hainan black goat based on genotyping by pinpoint sequencing of liquid captured targets (cGPS). A total of 45,588 candidate SNP sites were obtained, 10,677 of which representative SNP sites were selected to design probes, which finally covered 9,993 intervals and formed a 10K cGPS liquid cBMC genomic dataDevelopment and verification of a 10K liquid chip for Hainan black goat based on genotyping by pinpoint sequencing of liquid captured targets.PMC11075337No. YSPTZX202013ZDYF2021XDNY174CARS-38No. YSPTZX202153ZY2022HN09Zhang WChen QMan CHe MWang FGao HChen SMeng YDu LCheng YWu YWu HfalseDevelopment and verification of a 10K liquid chip for Hainan black goat based on genotyping by pinpoint sequencing of liquid captured targets.<h4>Background</h4>China has thousands years of goat breeding and abundant goat genetic resources. Additionally, the Hainan black goat is one of the high-quality local goat breeds in China. In order to conserve the germplasm resources of the Hainan black goat, facilitate its genetic improvement and further protect the genetic diversity of goats, it is urgent to develop a single nucleotide polymorphism (SNP) chip for Hainan black goat.<h4>Results</h4>In this study, we aimed to design a 10K liquid chip for Hainan black goat based on genotyping by pinpoint sequencing of liquid captured targets (cGPS). A total of 45,588 candidate SNP sites were obtained, 10,677 of which representative SNP sites were selected to design probes, which finally covered 9,993 intervals and formed a 10K cGPS liquid c2024-01-01T00:00:00Z2024 May2026-04-08T18:50:21.722Z2025-08-16T03:06:24.572ZS-EPMC110753373871495010.1186/s12863-024-01228-8