biostudies-literatureGross RSNIDA NIH HHSNIAID NIH HHSFoundation for the National Institutes of HealthNHLBI NIH HHSe0285635https://www.ebi.ac.uk/biostudies/studies/S-EPMC11075869biostudies-literatureUnknown19(5)<h4>Importance</h4>The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae of SARS-CoV-2 [PASC] or "Long COVID") in children and young adults remain unknown. Studies must address the urgent need to define PASC, its mechanisms, and potential treatment targets in children and young adults.<h4>Observations</h4>We describe the protocol for the Pediatric Observational Cohort Study of the NIH's REsearching COVID to Enhance Recovery (RECOVER) Initiative. RECOVER-Pediatrics is an observational meta-cohort study of caregiver-child pairs (birth through 17 years) and young adults (18 through 25 years), recruited from more than 100 sites across the US. This report focuses on two of four cohorts that comprise RECOVER-Pediatrics: 1) a de novo RECOVER prospective cohort oPloS oneResearching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design.PMC11075869OT2HL156812OT2HL161847OT2 HL161847U24 DA041147OT2HL161841K23 AI159518Baker FCAhmed STruong DTLim PPCUdosen MMAnderson BRHester CMMuller-Oehring EMTantisira KGAlshawabkeh ANLisdahl KMShakti DRussell MWHasbani KOsakwe OFlaherman VJWood MJSabati AANolan SMSchechter MSChan JElliott AJTalavera-Barber MMDasgupta SMcCulloh RJBueler EFoxe JJZempsky WTSanil YRosenzweig EBKinser PAHong TKFMorgan LMFriedman NPPortman MAJernigan TLMcCrindle BWGaur SMendelsohn ALMiller JRosas JMSelvarangan RMohandas SRandall IGKasmarcak TJGross RSD'Sa VOliveira CRGennaro MLRaissy HChibnik LBKarlson EWHuentelman MSexson Tejtel SKDapretto MLaird ARNess-Cochinwala MGallagher RThaweethai TChang LBarch DMHarahsheh ASNeale MCOster MECowan KClifton RGTrachtenberg FGage Witvliet MStein CRAupperle RLSalisbury ALZimmerman EDreyer BPHorowitz CRLandeo-Gutierrez JWarner MRRao SHill SBhuiyan SMilner JDElias MDBradford TEvans DNIrby KReeder HTKluko MJLamendola-Essel MFRECOVER-Pediatric ConsortiumWatson SEMudumbi PCBalaraman VHandler SHebson CWood JCMetz TDAschner JLKleinman LCHeath ACThacker DStockwell MSWerzberger ASharma KJacobus JRhee KECasey BJFaustino EVSLang SMForsha DHobart-Porter LDionne AWeyer JCChrisant MHsia DSFoulkes ASClark DBLarson CLDehority WStevenson MDBogie ALMitchell ECBanerjee DJacoby VLDummer KBAkerlundh ASnowden JNThomason MEAtz AMKatz SDClouser KNCottrell LFiks AGFry GKaelber DCEsquenazi-Karonika SPayne RMCicek MSGray KMMcHugh KHeitzeg MMSzmuszkovicz JSrivastava SWarburton DBuchbinder NCJone PNHummel KDKosut JSYin HSBaskin-Sommers AGee DGNahin ERSqueglia LMBukulmez HTeufel RJBind MCNewburger JWSato AIfalseResearching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design.<h4>Importance</h4>The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae of SARS-CoV-2 [PASC] or "Long COVID") in children and young adults remain unknown. Studies must address the urgent need to define PASC, its mechanisms, and potential treatment targets in children and young adults.<h4>Observations</h4>We describe the protocol for the Pediatric Observational Cohort Study of the NIH's REsearching COVID to Enhance Recovery (RECOVER) Initiative. RECOVER-Pediatrics is an observational meta-cohort study of caregiver-child pairs (birth through 17 years) and young adults (18 through 25 years), recruited from more than 100 sites across the US. This report focuses on two of four cohorts that comprise RECOVER-Pediatrics: 1) a de novo RECOVER prospective cohort o2024-01-01T00:00:00Z20242026-06-01T08:04:13.055Z2026-04-08T10:48:40.377ZS-EPMC110758693871367310.1371/journal.pone.0285635