biostudies-literatureGaliero RRegione Campaniae0296495https://www.ebi.ac.uk/biostudies/studies/S-EPMC11075870biostudies-literatureUnknown19(5)<h4>Background & aims</h4>SARS-Cov-2 infection manifests as a wide spectrum of clinical presentation and even now, despite the global spread of the vaccine, contagiousness is still elevated. The aim of the study was the evaluation of the impact of liver fibrosis assessed by FIB-4 and liver impairment, assessed by cytolysis indices, on intrahospital mortality in COVID-19 subjects.<h4>Methods</h4>This is a retrospective observational cohort study, which involved 23 COVID Hospital Units in Campania Region, Italy. Exposure variables were collected during hospital admission and at discharge. According to FIB-4 values, we subdivided the overall population in three groups (FIB-4<1.45; 1.45<FIB-4<3.25; FIB-4>3.25), respectively group 1,2,3.<h4>Results</h4>At the end of the study, 938 individuals hPloS oneImpact of liver fibrosis on COVID-19 in-hospital mortality in Southern Italy.PMC11075870POR Campania FESR 2014/2020, code SURF 21058BP000000020_CUP B63C22001210007Sbreglia CCOVOCA Study GroupFraganza FDe Lucia Sposito PNumis FEsposito VRinaldi LBeccia DCoppola CDi Micco PChiodini PSimeon VAdinolfi LENasti RAlfano MColantuoni SScarano FCalabria GSardu CEpifani RSasso FCMedicamento GGaliero RVetrano EMaggi PPolverino BPagano ARescigno CCaturano ADi Salvo JNevola RRomano ABrin CMaturo NPerrella AMarfella RParrella RCoppola NCalabrese CLoffredo GBologna CDi Domenico MNunziata MfalseImpact of liver fibrosis on COVID-19 in-hospital mortality in Southern Italy.<h4>Background & aims</h4>SARS-Cov-2 infection manifests as a wide spectrum of clinical presentation and even now, despite the global spread of the vaccine, contagiousness is still elevated. The aim of the study was the evaluation of the impact of liver fibrosis assessed by FIB-4 and liver impairment, assessed by cytolysis indices, on intrahospital mortality in COVID-19 subjects.<h4>Methods</h4>This is a retrospective observational cohort study, which involved 23 COVID Hospital Units in Campania Region, Italy. Exposure variables were collected during hospital admission and at discharge. According to FIB-4 values, we subdivided the overall population in three groups (FIB-4<1.45; 1.45<FIB-4<3.25; FIB-4>3.25), respectively group 1,2,3.<h4>Results</h4>At the end of the study, 938 individuals h2024-01-01T00:00:00Z20242026-06-01T17:26:32.318Z2026-04-08T14:13:01.703ZS-EPMC110758703871373110.1371/journal.pone.0296495