{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nguyen NH"],"funding":["NIA NIH HHS","Oregon Health and Science University","NIMH NIH HHS","National Institute of Mental Health","NINDS NIH HHS","NIAMS NIH HHS"],"pagination":["e32964"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11076170"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["195(4)"],"pubmed_abstract":["The Research Domain Criteria (RDoC) initiative was established by the US National Institute of Mental Health as a multilevel, disorder-agnostic framework for analysis of human psychopathology through designated domains and constructs, including the \"Positive Valence Systems\" domain focused on reward-related behavior. This study investigates the reward valuation subconstruct of \"effort\" and its association with genetic markers, functional neurobiological pathways, and polygenic risk scores for psychopathology in 1215 children aged 6-12 and their parents (n = 1044). All participants completed the effort expenditure for rewards task (EEfRT), which assesses \"effort\" according to two quantitative measures: hard-task choice and reward sensitivity. Genetic association analyses were undertaken in "],"journal":["American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics"],"pubmed_title":["Novel genome-wide associations for effort valuation and psychopathology in children and adults."],"pmcid":["PMC11076170"],"funding_grant_id":["U01AR076092‐01A1","R01 AG054002","R21MH126494","R01AG064955","R21 MH126494","1R21MH1264940","R01MH116037","R01 MH101519","R01MH101519","R01 NS128535","R01AG054002","R01 MH116037","1R01NS128535 – 01","U01AR076092-01A1","1R01NS128535 - 01","U01 AR076092","R01 AG064955"],"pubmed_authors":["Fremont WP","Mazza TM","Hess JL","Blatt SD","Albert AB","Elfstrom S","Glatt SJ","Forken P","Nguyen NH","Faraone SV"],"additional_accession":[]},"is_claimable":false,"name":"Novel genome-wide associations for effort valuation and psychopathology in children and adults.","description":"The Research Domain Criteria (RDoC) initiative was established by the US National Institute of Mental Health as a multilevel, disorder-agnostic framework for analysis of human psychopathology through designated domains and constructs, including the \"Positive Valence Systems\" domain focused on reward-related behavior. This study investigates the reward valuation subconstruct of \"effort\" and its association with genetic markers, functional neurobiological pathways, and polygenic risk scores for psychopathology in 1215 children aged 6-12 and their parents (n = 1044). All participants completed the effort expenditure for rewards task (EEfRT), which assesses \"effort\" according to two quantitative measures: hard-task choice and reward sensitivity. Genetic association analyses were undertaken in ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-06-01T11:48:05.46Z","creation":"2026-04-08T11:56:07.777Z"},"accession":"S-EPMC11076170","cross_references":{"pubmed":["37953388"],"doi":["10.1002/ajmg.b.32964"]}}