{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(4)"],"submitter":["Zhang W"],"pubmed_abstract":["Although sorafenib is the first-line therapeutic agent for advanced hepatocellular carcinoma (HCC), the development of drug resistance in HCC cells limits its clinical efficacy. However, the key factors involved in mediating the sorafenib resistance of HCC cells and the underlying mechanisms have not been elucidated. In this study, we generated sorafenib-resistant HCC cell lines, and our data demonstrate that HLA-F locus-adjacent transcript 10 (FAT10), a ubiquitin-like protein, is markedly upregulated in sorafenib-resistant HCC cells and that reducing the expression of FAT10 in sorafenib-resistant HCC cells increases sensitivity to sorafenib. Mechanistically, FAT10 stabilizes the expression of the PTEN-specific E3 ubiquitin ligase NEDD4 that causes downregulation of PTEN, thereby inducing "],"journal":["American journal of cancer research"],"pagination":["1523-1544"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11076247"],"repository":["biostudies-literature"],"pubmed_title":["FAT10 mediates the sorafenib-resistance of hepatocellular carcinoma cells by stabilizing E3 ligase NEDD4 to enhance PTEN/AKT pathway-induced autophagy."],"pmcid":["PMC11076247"],"pubmed_authors":["Zhang W","Ye M","Zhang D","Li J","Liu L","Shao J","Du D","Lu H","Chen Z","Chen L","Wang W","Yu X"],"additional_accession":[]},"is_claimable":false,"name":"FAT10 mediates the sorafenib-resistance of hepatocellular carcinoma cells by stabilizing E3 ligase NEDD4 to enhance PTEN/AKT pathway-induced autophagy.","description":"Although sorafenib is the first-line therapeutic agent for advanced hepatocellular carcinoma (HCC), the development of drug resistance in HCC cells limits its clinical efficacy. However, the key factors involved in mediating the sorafenib resistance of HCC cells and the underlying mechanisms have not been elucidated. In this study, we generated sorafenib-resistant HCC cell lines, and our data demonstrate that HLA-F locus-adjacent transcript 10 (FAT10), a ubiquitin-like protein, is markedly upregulated in sorafenib-resistant HCC cells and that reducing the expression of FAT10 in sorafenib-resistant HCC cells increases sensitivity to sorafenib. Mechanistically, FAT10 stabilizes the expression of the PTEN-specific E3 ubiquitin ligase NEDD4 that causes downregulation of PTEN, thereby inducing ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-02T06:09:11.999Z","creation":"2026-04-15T03:10:06.259Z"},"accession":"S-EPMC11076247","cross_references":{"pubmed":["38726263"],"doi":["10.62347/epit4481","10.62347/EPIT4481"]}}