{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang S"],"funding":["The Top-level Clinical Discipline Project of Shanghai Pudong","National Key R&D Program “Stem Cell and Transformation Research” Key Special Project","National Natural Science Foundation of China","National Key R&D Program \"Stem Cell and Transformation Research\" Key Special Project"],"pagination":["10457"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11076290"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Coagulation alterations manifest early after severe burns and are closely linked to mortality outcomes. Nevertheless, the precise characterization of coagulation changes associated with early mortality remains elusive. We examined alterations in indicators linked to mortality outcomes at both the transcriptomic and clinical characteristic levels. At the transcriptomic level, we pinpointed 28 differentially expressed coagulation-related genes (DECRGs) following burn injuries and endeavored to validate their causal relationships through Mendelian randomization. DECRGs tied to survival exhibit a significant association with neutrophil function, wherein the expression of CYP4F2 and P2RX1 serves as robust predictors of fatal outcomes. In terms of clinical indicators, early levels of D-dimer and"],"journal":["Scientific reports"],"pubmed_title":["Identification of early coagulation changes associated with survival outcomes post severe burns from multiple perspectives."],"pmcid":["PMC11076290"],"funding_grant_id":["81701899","2019YFA0110601","82160376","PWYgf2021-03"],"pubmed_authors":["Ma Q","Yin X","Chang L","Liao X","Wang D","Wu C","Zhu F","Liu R","Xin H","Wang L","Liu X","Li X","Huang S","Chen Z","Guo G","Shen T","Tang W","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"Identification of early coagulation changes associated with survival outcomes post severe burns from multiple perspectives.","description":"Coagulation alterations manifest early after severe burns and are closely linked to mortality outcomes. Nevertheless, the precise characterization of coagulation changes associated with early mortality remains elusive. We examined alterations in indicators linked to mortality outcomes at both the transcriptomic and clinical characteristic levels. At the transcriptomic level, we pinpointed 28 differentially expressed coagulation-related genes (DECRGs) following burn injuries and endeavored to validate their causal relationships through Mendelian randomization. DECRGs tied to survival exhibit a significant association with neutrophil function, wherein the expression of CYP4F2 and P2RX1 serves as robust predictors of fatal outcomes. In terms of clinical indicators, early levels of D-dimer and","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-03T06:49:15.995Z","creation":"2026-04-25T03:21:53.927Z"},"accession":"S-EPMC11076290","cross_references":{"pubmed":["38714778"],"doi":["10.1038/s41598-024-61194-0"]}}