biostudies-literatureDi YU.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)U.S. Department of Health & Human Services | NIH | National Institute of Mental Health540https://www.ebi.ac.uk/biostudies/studies/S-EPMC11076565biostudies-literatureUnknown7(1)The genetic influence on human vocal pitch in tonal and non-tonal languages remains largely unknown. In tonal languages, such as Mandarin Chinese, pitch changes differentiate word meanings, whereas in non-tonal languages, such as Icelandic, pitch is used to convey intonation. We addressed this question by searching for genetic associations with interindividual variation in median pitch in a Chinese major depression case-control cohort and compared our results with a genome-wide association study from Iceland. The same genetic variant, rs11046212-T in an intron of the ABCC9 gene, was one of the most strongly associated loci with median pitch in both samples. Our meta-analysis revealed four genome-wide significant hits, including two novel associations. The discovery of genetic variants influencing vocal pitch across both tonal and non-tonal languages suggests the possibility of a common genetic contribution to the human vocal system shared in two distinct populations with languages that differ in tonality (Icelandic and Mandarin).Communications biologyGenetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages.PMC11076565MH-122596Alwan ARavi VMefford JFlint JRahmani EWang JGorla ADi YZhu TfalseGenetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages.The genetic influence on human vocal pitch in tonal and non-tonal languages remains largely unknown. In tonal languages, such as Mandarin Chinese, pitch changes differentiate word meanings, whereas in non-tonal languages, such as Icelandic, pitch is used to convey intonation. We addressed this question by searching for genetic associations with interindividual variation in median pitch in a Chinese major depression case-control cohort and compared our results with a genome-wide association study from Iceland. The same genetic variant, rs11046212-T in an intron of the ABCC9 gene, was one of the most strongly associated loci with median pitch in both samples. Our meta-analysis revealed four genome-wide significant hits, including two novel associations. The discovery of genetic variants influencing vocal pitch across both tonal and non-tonal languages suggests the possibility of a common genetic contribution to the human vocal system shared in two distinct populations with languages that differ in tonality (Icelandic and Mandarin).2024-01-01T00:00:00Z2024 May2026-04-08T19:55:08.623Z2026-04-08T14:34:41.255ZS-EPMC110765653871479810.1038/s42003-024-06198-2