biostudies-literatureUnknown15Zhao J<h4>Introduction</h4>Valsa canker, caused by <i>Cytospora mali</i>, is a destructive disease in apple production. However, the mechanism by which apple defend against <i>C. mali</i> infection remains unclear.<h4>Methods</h4>In this study, the integrative transcriptional and metabolic analysis were used to investigate the responses of the 'Jin Hong' apple branches to the invasion of <i>C. mali</i>.<h4>Results and discussion</h4>Results showed that the differentially expressed genes were mainly enriched in the pathways of carbon metabolism, photosynthesis-antenna proteins, and biosynthesis of amino acids pathways. Additionally, the differentially accumulated metabolites were significantly enriched in aminoacyl-tRNA biosynthesis, fructose and mannose metabolism, and alanine, aspartate, and glFrontiers in microbiology1394447https://www.ebi.ac.uk/biostudies/studies/S-EPMC11076740biostudies-literatureIntegrated transcriptome and metabolome profiling reveals mechanisms underlying the infection of <i>Cytospora mali</i> in "Jin Hong" branches.PMC11076740Li ZSun PGuo YZhao JShi YfalseIntegrated transcriptome and metabolome profiling reveals mechanisms underlying the infection of <i>Cytospora mali</i> in "Jin Hong" branches.<h4>Introduction</h4>Valsa canker, caused by <i>Cytospora mali</i>, is a destructive disease in apple production. However, the mechanism by which apple defend against <i>C. mali</i> infection remains unclear.<h4>Methods</h4>In this study, the integrative transcriptional and metabolic analysis were used to investigate the responses of the 'Jin Hong' apple branches to the invasion of <i>C. mali</i>.<h4>Results and discussion</h4>Results showed that the differentially expressed genes were mainly enriched in the pathways of carbon metabolism, photosynthesis-antenna proteins, and biosynthesis of amino acids pathways. Additionally, the differentially accumulated metabolites were significantly enriched in aminoacyl-tRNA biosynthesis, fructose and mannose metabolism, and alanine, aspartate, and gl2024-01-01T00:00:00Z20242026-05-20T03:14:36.564Z2026-05-20T03:07:52.832ZS-EPMC110767403872160110.3389/fmicb.2024.1394447