biostudies-literatureWang SShanghai Anticancer Association EYAS PROJECTengineering and medical science cooperation project of Shanghai Jiao Tong University570https://www.ebi.ac.uk/biostudies/studies/S-EPMC11077837biostudies-literatureUnknown24(1)<h4>Background</h4>Gastric cancer (GC) is one of the most prevalent malignant tumors worldwide and is associated with high morbidity and mortality rates. However, the specific biomarkers used to predict the postoperative prognosis of patients with gastric cancer remain unknown. Recent research has shown that the tumor microenvironment (TME) has an increasingly positive effect on anti-tumor activity. This study aims to build signatures to study the effect of certain genes on gastric cancer.<h4>Methods</h4>Expression profiles of 37 T cell-related genes and their TME characteristics were comprehensively analyzed. A risk signature was constructed and validated based on the screened T cell-related genes, and the roles of hub genes in GC were experimentally validated.<h4>Results</h4>A novel T ceBMC cancerComprehensive analysis of T-cell regulatory factors and tumor immune microenvironment in stomach adenocarcinoma.PMC11077837SACA-CY22801YG2023QNA10Zhang WZhu ZZhuang CWang SChen LChen YXu JWu XLiu WfalseComprehensive analysis of T-cell regulatory factors and tumor immune microenvironment in stomach adenocarcinoma.<h4>Background</h4>Gastric cancer (GC) is one of the most prevalent malignant tumors worldwide and is associated with high morbidity and mortality rates. However, the specific biomarkers used to predict the postoperative prognosis of patients with gastric cancer remain unknown. Recent research has shown that the tumor microenvironment (TME) has an increasingly positive effect on anti-tumor activity. This study aims to build signatures to study the effect of certain genes on gastric cancer.<h4>Methods</h4>Expression profiles of 37 T cell-related genes and their TME characteristics were comprehensively analyzed. A risk signature was constructed and validated based on the screened T cell-related genes, and the roles of hub genes in GC were experimentally validated.<h4>Results</h4>A novel T ce2024-01-01T00:00:00Z2024 May2026-06-01T18:49:05.96Z2026-05-19T03:07:12.494ZS-EPMC110778373871498710.1186/s12885-024-12302-w