{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hjort L"],"funding":["The Innovation Fund Denmark","Fhv. Dir. Leo Nielsen og Hustru Karen Margrethe Nielsens Legat for Lægevidenskabelig Grundforskning","Civilingeniør Frode V. Nyegaard og Hustru’s Fond","Novo Nordisk Foundation Center for Basic Metabolic Research","Lægeforeningens Forskningfond","Novo Nordisk Fonden","The Danish Diabetes Association","A.P. Møller Fonden"],"pagination":["61"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11077860"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Background
Diabetes in pregnancy is associated with increased risk of long-term metabolic disease in the offspring, potentially mediated by in utero epigenetic variation. Previously, we identified multiple differentially methylated single CpG sites in offspring of women with gestational diabetes mellitus (GDM), but whether stretches of differentially methylated regions (DMRs) can also be identified in adolescent GDM offspring is unknown. Here, we investigate which DNA regions in adolescent offspring are differentially methylated in blood by exposure to diabetes in pregnancy. The secondary aim was to characterize the RNA expression of the identified DMR, which contained the nc886 non-coding RNA.Methods
To identify DMRs, we employed the bump hunter method in samples from youn"],"journal":["Clinical epigenetics"],"pubmed_title":["Epigenetics of the non-coding RNA nc886 across blood, adipose tissue and skeletal muscle in offspring exposed to diabetes in pregnancy."],"pmcid":["PMC11077860"],"funding_grant_id":["NNF17SA0031406","NNF23OC0081177","NNF18CC0034900","09-067124"],"pubmed_authors":["Saffery R","Martino D","Olsen SF","Grunnet LG","Vaag AA","Manitta E","Houshmand-Oeregaard A","Hjort L","Mathiesen ER","Clausen TD","Barres R","Marques I","Kelstrup L","Dalgaard LT","Sorensen AE","Damm P","Bredgaard SS"],"additional_accession":[]},"is_claimable":false,"name":"Epigenetics of the non-coding RNA nc886 across blood, adipose tissue and skeletal muscle in offspring exposed to diabetes in pregnancy.","description":"Background
Diabetes in pregnancy is associated with increased risk of long-term metabolic disease in the offspring, potentially mediated by in utero epigenetic variation. Previously, we identified multiple differentially methylated single CpG sites in offspring of women with gestational diabetes mellitus (GDM), but whether stretches of differentially methylated regions (DMRs) can also be identified in adolescent GDM offspring is unknown. Here, we investigate which DNA regions in adolescent offspring are differentially methylated in blood by exposure to diabetes in pregnancy. The secondary aim was to characterize the RNA expression of the identified DMR, which contained the nc886 non-coding RNA.Methods
To identify DMRs, we employed the bump hunter method in samples from youn","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-04-08T19:51:32.07Z","creation":"2025-08-14T03:05:45.954Z"},"accession":"S-EPMC11077860","cross_references":{"pubmed":["38715048"],"doi":["10.1186/s13148-024-01673-3"]}}