{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gurung P"],"funding":["NIAID NIH HHS","HHS | NIH | National Institute of Allergy and Infectious Diseases"],"pagination":["e0285023"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11078010"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(5)"],"pubmed_abstract":["Condensin I is a pentameric complex that regulates the mitotic chromosome assembly in eukaryotes. The kleisin subunit CAP-H of the condensin I complex acts as a linchpin to maintain the structural integrity and loading of this complex on mitotic chromosomes. This complex is present in all eukaryotes and has recently been identified in <i>Plasmodium</i> spp. However, how this complex is assembled and whether the kleisin subunit is critical for this complex in these parasites are yet to be explored. To examine the role of PfCAP-H during cell division within erythrocytes, we generated an inducible PfCAP-H knockout parasite. We find that PfCAP-H is dynamically expressed during mitosis with the peak expression at the metaphase plate. PfCAP-H interacts with PfCAP-G and is a non-SMC member of the"],"journal":["mBio"],"pubmed_title":["PfCAP-H is essential for assembly of condensin I complex and karyokinesis during asexual proliferation of <i>Plasmodium falciparum</i>."],"pmcid":["PMC11078010"],"funding_grant_id":["R01 AI145941","R01AI145941"],"pubmed_authors":["Gurung P","McGee JP","Dvorin JD"],"additional_accession":[]},"is_claimable":false,"name":"PfCAP-H is essential for assembly of condensin I complex and karyokinesis during asexual proliferation of <i>Plasmodium falciparum</i>.","description":"Condensin I is a pentameric complex that regulates the mitotic chromosome assembly in eukaryotes. The kleisin subunit CAP-H of the condensin I complex acts as a linchpin to maintain the structural integrity and loading of this complex on mitotic chromosomes. This complex is present in all eukaryotes and has recently been identified in <i>Plasmodium</i> spp. However, how this complex is assembled and whether the kleisin subunit is critical for this complex in these parasites are yet to be explored. To examine the role of PfCAP-H during cell division within erythrocytes, we generated an inducible PfCAP-H knockout parasite. We find that PfCAP-H is dynamically expressed during mitosis with the peak expression at the metaphase plate. PfCAP-H interacts with PfCAP-G and is a non-SMC member of the","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-02T06:54:25.527Z","creation":"2026-04-15T03:15:33.049Z"},"accession":"S-EPMC11078010","cross_references":{"pubmed":["38564676"],"doi":["10.1128/mbio.02850-23"]}}