{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sivalogan K"],"funding":["National Institute of Environmental Health Sciences","NIEHS NIH HHS","National Institutes of Health","Bill and Melinda Gates Foundation"],"pagination":["102144"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11079463"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(5)"],"pubmed_abstract":["<h4>Background</h4>Maternal overweight and obesity has been associated with poor lactation performance including delayed lactogenesis and reduced duration. However, the effect on human milk composition is less well understood.<h4>Objectives</h4>We evaluated the relationship of maternal BMI on the human milk metabolome among Guatemalan mothers.<h4>Methods</h4>We used data from 75 Guatemalan mothers who participated in the Household Air Pollution Intervention Network trial. Maternal BMI was measured between 9 and <20 weeks of gestation. Milk samples were collected at a single time point using aseptic collection from one breast at 6 mo postpartum and analyzed using high-resolution mass spectrometry. A cross-sectional untargeted high-resolution metabolomics analysis was performed by coupling h"],"journal":["Current developments in nutrition"],"pubmed_title":["Human Milk Composition Is Associated with Maternal Body Mass Index in a Cross-Sectional, Untargeted Metabolomics Analysis of Human Milk from Guatemalan Mothers."],"pmcid":["PMC11079463"],"funding_grant_id":["T32 ES012870","1UM1HL134590","OPP1131279","P30 ES019776"],"pubmed_authors":["Liang D","Accardi C","Diaz-Artiga A","Hu X","Tran V","Sinharoy SS","Teeny SN","Sivalogan K","Clasen TF","Ramakrishnan U","Mollinedo E","Thompson LM"],"additional_accession":[]},"is_claimable":false,"name":"Human Milk Composition Is Associated with Maternal Body Mass Index in a Cross-Sectional, Untargeted Metabolomics Analysis of Human Milk from Guatemalan Mothers.","description":"<h4>Background</h4>Maternal overweight and obesity has been associated with poor lactation performance including delayed lactogenesis and reduced duration. However, the effect on human milk composition is less well understood.<h4>Objectives</h4>We evaluated the relationship of maternal BMI on the human milk metabolome among Guatemalan mothers.<h4>Methods</h4>We used data from 75 Guatemalan mothers who participated in the Household Air Pollution Intervention Network trial. Maternal BMI was measured between 9 and <20 weeks of gestation. Milk samples were collected at a single time point using aseptic collection from one breast at 6 mo postpartum and analyzed using high-resolution mass spectrometry. A cross-sectional untargeted high-resolution metabolomics analysis was performed by coupling h","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-02T01:37:04.631Z","creation":"2026-04-13T03:12:17.412Z"},"accession":"S-EPMC11079463","cross_references":{"pubmed":["38726027"],"doi":["10.1016/j.cdnut.2024.102144"]}}