{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27(5)"],"submitter":["Li Y"],"pubmed_abstract":["High salt can induce cardiac damage. The aim of this present study was to explore the effect and the mechanism of microRNA (miR)-142-3p on the cardiac fibrosis induced by high salt. Rats received high salt diet to induce cardiac fibrosis <i>in vivo</i>, and neonatal rat cardiac fibroblasts (NRCF) treated with sodium chloride (NaCl) to induce fibrosis <i>in vitro</i>. The fibrosis and mitochondrial autophagy levels were increased the heart and NRCF treated with NaCl, which were alleviated by miR-142-3p upregulation. The fibrosis and mitochondrial autophagy levels were elevated in NRCF after treating with miR-142-3p antagomiR. Optineurin (OPTN) expression was increased in the mitochondria of NRCF induced by NaCl, which was attenuated by miR-142-3p agomiR. OPTN downregulation inhibited the in"],"journal":["iScience"],"pagination":["109764"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11079474"],"repository":["biostudies-literature"],"pubmed_title":["MicroRNA-142-3p alleviated high salt-induced cardiac fibrosis via downregulating optineurin-mediated mitophagy."],"pmcid":["PMC11079474"],"pubmed_authors":["Liu Y","Li Y","Hu Y","Li P","Zhao K","Yang F"],"additional_accession":[]},"is_claimable":false,"name":"MicroRNA-142-3p alleviated high salt-induced cardiac fibrosis via downregulating optineurin-mediated mitophagy.","description":"High salt can induce cardiac damage. The aim of this present study was to explore the effect and the mechanism of microRNA (miR)-142-3p on the cardiac fibrosis induced by high salt. Rats received high salt diet to induce cardiac fibrosis <i>in vivo</i>, and neonatal rat cardiac fibroblasts (NRCF) treated with sodium chloride (NaCl) to induce fibrosis <i>in vitro</i>. The fibrosis and mitochondrial autophagy levels were increased the heart and NRCF treated with NaCl, which were alleviated by miR-142-3p upregulation. The fibrosis and mitochondrial autophagy levels were elevated in NRCF after treating with miR-142-3p antagomiR. Optineurin (OPTN) expression was increased in the mitochondria of NRCF induced by NaCl, which was attenuated by miR-142-3p agomiR. OPTN downregulation inhibited the in","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-01T05:25:37.5Z","creation":"2026-04-08T09:33:25.064Z"},"accession":"S-EPMC11079474","cross_references":{"pubmed":["38726368"],"doi":["10.1016/j.isci.2024.109764"]}}