{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McQuillan MA"],"funding":["University of Pennsylvania Center of Excellence in Environmental Toxicology","NIDDK NIH HHS","University of Pennsylvania","NIEHS NIH HHS","American Diabetes Association","National Institutes of Health","NIGMS NIH HHS"],"pagination":["927-938"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11080607"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["111(5)"],"pubmed_abstract":["Leukocyte telomere length (LTL) varies significantly across human populations, with individuals of African ancestry having longer LTL than non-Africans. However, the genetic and environmental drivers of LTL variation in Africans remain largely unknown. We report here on the relationship between LTL, genetics, and a variety of environmental and climatic factors in ethnically diverse African adults (n = 1,818) originating from Botswana, Tanzania, Ethiopia, and Cameroon. We observe significant variation in LTL among populations, finding that the San hunter-gatherers from Botswana have the longest leukocyte telomeres and that the Fulani pastoralists from Cameroon have the shortest telomeres. Genetic factors explain ∼50% of LTL variation among individuals. Moreover, we observe a significant neg"],"journal":["American journal of human genetics"],"pubmed_title":["Association between telomere length and Plasmodium falciparum malaria endemicity in sub-Saharan Africans."],"pmcid":["PMC11080607"],"funding_grant_id":["T32-ES019851","R35 GM134957-01","P30 DK019525","R35 GM134957","T32 ES019851","1-19-VSN-02"],"pubmed_authors":["Chanock SJ","Njamnshi AK","Hansen MEB","McQuillan MA","Meskel DW","Tishkoff SA","Fokunang C","Beggs W","Verhulst S","Aviv A","Nyambo T","Mpoloka SW","Mokone GG","Belay G"],"additional_accession":[]},"is_claimable":false,"name":"Association between telomere length and Plasmodium falciparum malaria endemicity in sub-Saharan Africans.","description":"Leukocyte telomere length (LTL) varies significantly across human populations, with individuals of African ancestry having longer LTL than non-Africans. However, the genetic and environmental drivers of LTL variation in Africans remain largely unknown. We report here on the relationship between LTL, genetics, and a variety of environmental and climatic factors in ethnically diverse African adults (n = 1,818) originating from Botswana, Tanzania, Ethiopia, and Cameroon. We observe significant variation in LTL among populations, finding that the San hunter-gatherers from Botswana have the longest leukocyte telomeres and that the Fulani pastoralists from Cameroon have the shortest telomeres. Genetic factors explain ∼50% of LTL variation among individuals. Moreover, we observe a significant neg","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-02T04:08:39.005Z","creation":"2025-04-21T21:44:30.792Z"},"accession":"S-EPMC11080607","cross_references":{"pubmed":["38701745"],"doi":["10.1016/j.ajhg.2024.04.003"]}}