{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dolgova N"],"funding":["Natural Sciences and Engineering Research Council of Canada","NCRR NIH HHS","Canada Foundation for Innovation","University of Saskatchewan","Canadian Institutes of Health Research","NIGMS NIH HHS","NIH HHS","CIHR","Saskatchewan Cancer Agency"],"pagination":["e86354"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11081632"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["Mediator of ERBB2-driven cell motility 1 (MEMO1) is an evolutionary conserved protein implicated in many biological processes; however, its primary molecular function remains unknown. Importantly, MEMO1 is overexpressed in many types of cancer and was shown to modulate breast cancer metastasis through altered cell motility. To better understand the function of MEMO1 in cancer cells, we analyzed genetic interactions of MEMO1 using gene essentiality data from 1028 cancer cell lines and found multiple iron-related genes exhibiting genetic relationships with MEMO1. We experimentally confirmed several interactions between MEMO1 and iron-related proteins in living cells, most notably, transferrin receptor 2 (<i>TFR</i>2), mitoferrin-2 (<i>SLC25A28</i>), and the global iron response regulator IRP"],"journal":["eLife"],"pubmed_title":["MEMO1 binds iron and modulates iron homeostasis in cancer cells."],"pmcid":["PMC11081632"],"funding_grant_id":["PJT-178246","R24 GM141526","S10 RR025512","S10 OD028492","PJT-156309","CFI-33364","P41 GM103399","RGPIN-2017-06822"],"pubmed_authors":["Vizeacoumar FS","Patry J","Dolgova N","Tonelli M","Uhlemann EE","Boniecki MT","Ralle M","Nouri P","Abbas SA","Freywald A","Ara A","Vizeacoumar FJ","Elhasasna H","Dmitriev OY"],"additional_accession":[]},"is_claimable":false,"name":"MEMO1 binds iron and modulates iron homeostasis in cancer cells.","description":"Mediator of ERBB2-driven cell motility 1 (MEMO1) is an evolutionary conserved protein implicated in many biological processes; however, its primary molecular function remains unknown. Importantly, MEMO1 is overexpressed in many types of cancer and was shown to modulate breast cancer metastasis through altered cell motility. To better understand the function of MEMO1 in cancer cells, we analyzed genetic interactions of MEMO1 using gene essentiality data from 1028 cancer cell lines and found multiple iron-related genes exhibiting genetic relationships with MEMO1. We experimentally confirmed several interactions between MEMO1 and iron-related proteins in living cells, most notably, transferrin receptor 2 (<i>TFR</i>2), mitoferrin-2 (<i>SLC25A28</i>), and the global iron response regulator IRP","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-06-02T08:25:45.934Z","creation":"2026-04-16T03:11:07.288Z"},"accession":"S-EPMC11081632","cross_references":{"pubmed":["38640016"],"doi":["10.7554/eLife.86354"]}}