biostudies-literatureChen JNHLBI NIH HHSNCI NIH HHSNIGMS NIH HHS1330-1347https://www.ebi.ac.uk/biostudies/studies/S-EPMC11081830biostudies-literatureUnknown134(10)<h4>Background</h4>Tetraspanin CD151 is highly expressed in endothelia and reinforces cell adhesion, but its role in vascular inflammation remains largely unknown.<h4>Methods</h4>In vitro molecular and cellular biological analyses on genetically modified endothelial cells, in vivo vascular biological analyses on genetically engineered mouse models, and in silico systems biology and bioinformatics analyses on CD151-related events.<h4>Results</h4>Endothelial ablation of <i>Cd151</i> leads to pulmonary and cardiac inflammation, severe sepsis, and perilous COVID-19, and endothelial CD151 becomes downregulated in inflammation. Mechanistically, CD151 restrains endothelial release of proinflammatory molecules for less leukocyte infiltration. At the subcellular level, CD151 determines the integritCirculation researchCD151 Maintains Endolysosomal Protein Quality to Inhibit Vascular Inflammation.PMC11081830R01 HL132553R01 HL133951R01 HL172447R01 HL148810R01 GM135547R01 HL137819R01 HL164014R01 HL162299P30 CA225520P20 GM103639Huang CFung KMSonnenberg AZhang XAWu DPapin JFWang JRice HCQu RDing YGiles CBStipp CSSchiller HBReuter DNWang XWalters MSChen JHays FAKanie TWang DWZhao YYSubramaniyan BZuo HJiang CLiu BMayr CHDai JWren JDGeorgescu CfalseCD151 Maintains Endolysosomal Protein Quality to Inhibit Vascular Inflammation.<h4>Background</h4>Tetraspanin CD151 is highly expressed in endothelia and reinforces cell adhesion, but its role in vascular inflammation remains largely unknown.<h4>Methods</h4>In vitro molecular and cellular biological analyses on genetically modified endothelial cells, in vivo vascular biological analyses on genetically engineered mouse models, and in silico systems biology and bioinformatics analyses on CD151-related events.<h4>Results</h4>Endothelial ablation of <i>Cd151</i> leads to pulmonary and cardiac inflammation, severe sepsis, and perilous COVID-19, and endothelial CD151 becomes downregulated in inflammation. Mechanistically, CD151 restrains endothelial release of proinflammatory molecules for less leukocyte infiltration. At the subcellular level, CD151 determines the integrit2024-01-01T00:00:00Z2024 May2026-06-02T12:08:24.809Z2026-04-18T03:11:00.251ZS-EPMC110818303855711910.1161/circresaha.123.32319010.1161/CIRCRESAHA.123.323190