{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(4)"],"submitter":["Yousuf B"],"funding":["Canadian Blood Services","Health Canada"],"pubmed_abstract":["<i>Staphylococcus epidermidis</i> is one of the predominant bacterial contaminants in platelet concentrates (PCs), a blood component used to treat bleeding disorders. PCs are a unique niche that triggers biofilm formation, the main pathomechanism of <i>S. epidermidis</i> infections. We performed whole genome sequencing of four <i>S. epidermidis</i> strains isolated from skin of healthy human volunteers (AZ22 and AZ39) and contaminated PCs (ST10002 and ST11003) to unravel phylogenetic relationships and decipher virulence mechanisms compared to 24 complete <i>S. epidermidis</i> genomes in GenBank. AZ39 and ST11003 formed a separate unique lineage with strains 14.1 .R1 and SE95, while AZ22 formed a cluster with 1457 and ST10002 closely grouped with FDAAGOS_161. The four isolates were assigned"],"journal":["Access microbiology"],"pagination":["000780.v3"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11083402"],"repository":["biostudies-literature"],"pubmed_title":["Comparative virulome analysis of four Staphylococcus epidermidis strains from human skin and platelet concentrates using whole genome sequencing."],"pmcid":["PMC11083402"],"pubmed_authors":["Flint A","Weedmark K","Pagotto F","Ramirez-Arcos S","Yousuf B"],"additional_accession":[]},"is_claimable":false,"name":"Comparative virulome analysis of four Staphylococcus epidermidis strains from human skin and platelet concentrates using whole genome sequencing.","description":"<i>Staphylococcus epidermidis</i> is one of the predominant bacterial contaminants in platelet concentrates (PCs), a blood component used to treat bleeding disorders. PCs are a unique niche that triggers biofilm formation, the main pathomechanism of <i>S. epidermidis</i> infections. We performed whole genome sequencing of four <i>S. epidermidis</i> strains isolated from skin of healthy human volunteers (AZ22 and AZ39) and contaminated PCs (ST10002 and ST11003) to unravel phylogenetic relationships and decipher virulence mechanisms compared to 24 complete <i>S. epidermidis</i> genomes in GenBank. AZ39 and ST11003 formed a separate unique lineage with strains 14.1 .R1 and SE95, while AZ22 formed a cluster with 1457 and ST10002 closely grouped with FDAAGOS_161. The four isolates were assigned","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-01T17:16:18.671Z","creation":"2025-07-25T03:08:07.539Z"},"accession":"S-EPMC11083402","cross_references":{"pubmed":["38737800"],"doi":["10.1099/acmi.0.000780.v3"]}}