{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Park M"],"funding":["Korea Institute of Oriental Medicine","National Research Foundation of Korea (NRF)","National Research Foundation of Korea"],"pagination":["4636"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11083729"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(9)"],"pubmed_abstract":["We characterized the therapeutic biological modes of action of several terpenes in <i>Poria cocos</i> F.A Wolf (PC) and proposed a broad therapeutic mode of action for PC. Molecular docking and drug-induced transcriptome analysis were performed to confirm the pharmacological mechanism of PC terpene, and a new analysis method, namely diffusion network analysis, was proposed to verify the mechanism of action against Alzheimer's disease. We confirmed that the compound that exists only in PC has a unique mechanism through statistical-based docking analysis. Also, docking and transcriptomic analysis results could reflect results in clinical practice when used complementarily. The detailed pharmacological mechanism of PC was confirmed by constructing and analyzing the Alzheimer's disease diffusi"],"journal":["International journal of molecular sciences"],"pubmed_title":["Effect of <i>Poria cocos</i> Terpenes: Verifying Modes of Action Using Molecular Docking, Drug-Induced Transcriptomes, and Diffusion Network Analyses."],"pmcid":["PMC11083729"],"funding_grant_id":["NSN2312040","KSN1722122","NSN2311040"],"pubmed_authors":["Kim NS","Lee SY","Yi JM","Park M","Lee H"],"additional_accession":[]},"is_claimable":false,"name":"Effect of <i>Poria cocos</i> Terpenes: Verifying Modes of Action Using Molecular Docking, Drug-Induced Transcriptomes, and Diffusion Network Analyses.","description":"We characterized the therapeutic biological modes of action of several terpenes in <i>Poria cocos</i> F.A Wolf (PC) and proposed a broad therapeutic mode of action for PC. Molecular docking and drug-induced transcriptome analysis were performed to confirm the pharmacological mechanism of PC terpene, and a new analysis method, namely diffusion network analysis, was proposed to verify the mechanism of action against Alzheimer's disease. We confirmed that the compound that exists only in PC has a unique mechanism through statistical-based docking analysis. Also, docking and transcriptomic analysis results could reflect results in clinical practice when used complementarily. The detailed pharmacological mechanism of PC was confirmed by constructing and analyzing the Alzheimer's disease diffusi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-05-26T20:01:07.651Z","creation":"2026-05-25T03:07:04.239Z"},"accession":"S-EPMC11083729","cross_references":{"pubmed":["38731856"],"doi":["10.3390/ijms25094636"]}}