biostudies-literatureXiao DDalian Science and Technology Innovation Fund ProjectLiaoning Provincial Department of Education Basic Scientific Research ProjectDalian University Research Platform Project2112https://www.ebi.ac.uk/biostudies/studies/S-EPMC11085523biostudies-literatureUnknown29(9)A new quinazolinone alkaloid named peniquinazolinone A (<b>1</b>), as well as eleven known compounds, 2-(2-hydroxy-3-phenylpropionamido)-<i>N</i>-methylbenzamide (<b>2</b>), viridicatin (<b>3</b>), viridicatol (<b>4</b>), (±)-cyclopeptin (<b>5a</b>/<b>5b</b>), dehydrocyclopeptin (<b>6</b>), cyclopenin (<b>7</b>), cyclopenol (<b>8</b>), methyl-indole-3-carboxylate (<b>9</b>), 2,5-dihydroxyphenyl acetate (<b>10</b>), methyl <i>m</i>-hydroxyphenylacetate (<b>11</b>), and conidiogenone B (<b>12</b>), were isolated from the endophytic <i>Penicillium</i> sp. HJT-A-6. The chemical structures of all the compounds were elucidated by comprehensive spectroscopic analysis, including 1D and 2D NMR and HRESIMS. The absolute configuration at C-13 of peniquinazolinone A (<b>1</b>) was established by applyMolecules (Basel, Switzerland)A New Quinazolinone Alkaloid along with Known Compounds with Seed-Germination-Promoting Activity from <i>Rhodiola tibetica</i> Endophytic Fungus <i>Penicillium</i> sp. HJT-A-6.PMC11085523JYTQN2023100202101YB08LJKFZ202202872022JJ12WZ059Lu XZhang XFeng WXiao DWang YFeng BGao CfalseA New Quinazolinone Alkaloid along with Known Compounds with Seed-Germination-Promoting Activity from <i>Rhodiola tibetica</i> Endophytic Fungus <i>Penicillium</i> sp. HJT-A-6.A new quinazolinone alkaloid named peniquinazolinone A (<b>1</b>), as well as eleven known compounds, 2-(2-hydroxy-3-phenylpropionamido)-<i>N</i>-methylbenzamide (<b>2</b>), viridicatin (<b>3</b>), viridicatol (<b>4</b>), (±)-cyclopeptin (<b>5a</b>/<b>5b</b>), dehydrocyclopeptin (<b>6</b>), cyclopenin (<b>7</b>), cyclopenol (<b>8</b>), methyl-indole-3-carboxylate (<b>9</b>), 2,5-dihydroxyphenyl acetate (<b>10</b>), methyl <i>m</i>-hydroxyphenylacetate (<b>11</b>), and conidiogenone B (<b>12</b>), were isolated from the endophytic <i>Penicillium</i> sp. HJT-A-6. The chemical structures of all the compounds were elucidated by comprehensive spectroscopic analysis, including 1D and 2D NMR and HRESIMS. The absolute configuration at C-13 of peniquinazolinone A (<b>1</b>) was established by apply2024-01-01T00:00:00Z2024 May2025-08-31T03:20:12.811Z2025-08-31T03:08:41.979ZS-EPMC110855233873160310.3390/molecules29092112