biostudies-literatureUnknown62(1)Dong XClinical and Experimental Research<h4>Context</h4>Yi-Shen-Hua-Shi (YSHS) is a traditional Chinese medicine that treats chronic kidney disease (CKD). However, its efficacy in reducing proteinuria and underlying mechanisms is unknown.<h4>Objective</h4>This single-center randomized controlled trial explored whether YSHS could improve proteinuria and modulate the gut microbiota.<h4>Materials and methods</h4>120 CKD patients were enrolled and randomized to receive the renin-angiotensin-aldosterone system (RAAS) inhibitor plus YSHS (<i>n</i> = 56) or RAAS inhibitor (<i>n</i> = 47) alone for 4 months, and 103 patients completed the study. We collected baseline and follow-up fecal samples and clinical outcomes from participants. Total bacterial DNA was extracted, and the fecal microbiome was analyzed using bioinformatics.<h4>ResulPharmaceutical biology356-366https://www.ebi.ac.uk/biostudies/studies/S-EPMC11085992biostudies-literatureYi-Shen-Hua-Shi regulates intestinal microbiota dysbiosis and protects against proteinuria in patients with chronic kidney disease: a randomized controlled study.PMC11085992Li WLi YLiu ZDong XZhang JFu WJia LZhang AfalseYi-Shen-Hua-Shi regulates intestinal microbiota dysbiosis and protects against proteinuria in patients with chronic kidney disease: a randomized controlled study.<h4>Context</h4>Yi-Shen-Hua-Shi (YSHS) is a traditional Chinese medicine that treats chronic kidney disease (CKD). However, its efficacy in reducing proteinuria and underlying mechanisms is unknown.<h4>Objective</h4>This single-center randomized controlled trial explored whether YSHS could improve proteinuria and modulate the gut microbiota.<h4>Materials and methods</h4>120 CKD patients were enrolled and randomized to receive the renin-angiotensin-aldosterone system (RAAS) inhibitor plus YSHS (<i>n</i> = 56) or RAAS inhibitor (<i>n</i> = 47) alone for 4 months, and 103 patients completed the study. We collected baseline and follow-up fecal samples and clinical outcomes from participants. Total bacterial DNA was extracted, and the fecal microbiome was analyzed using bioinformatics.<h4>Resul2024-01-01T00:00:00Z2024 Dec2026-06-03T04:26:39.309Z2026-04-24T03:09:38.372ZS-EPMC110859923872066610.1080/13880209.2024.2345080