{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(8)"],"submitter":["Huang S"],"pubmed_abstract":["<h4>Aim</h4>In 2019, to examine the functions of METTL3 in liver and underlying mechanisms, we generated mice with hepatocyte-specific METTL3 homozygous knockout (METTL3Δhep) by simultaneously crossing METTL3fl/fl mice with Alb-iCre mice (GPT) or Alb-Cre mice (JAX), respectively. In this study, we explored the potential reasons why hepatocyte-specific METTL3 homozygous disruption by Alb-iCre mice (GPT), but not by Alb-Cre mice (JAX), resulted in acute liver failure (ALF) and then postnatal lethality.<h4>Main methods</h4>Mice with hepatocyte-specific METTL3 knockout were generated by simultaneously crossing METTL3fl/fl mice with Alb-iCre mice (GPT; Strain No. T003814) purchased from the GemPharmatech Co., Ltd., (Nanjing, China) or with Alb-Cre mice (JAX; Strain No. 003574) obtained from The"],"journal":["Aging"],"pagination":["7217-7248"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11087113"],"repository":["biostudies-literature"],"pubmed_title":["Hepatocyte-specific METTL3 ablation by Alb-iCre mice (GPT), but not by Alb-Cre mice (JAX), resulted in acute liver failure (ALF) and postnatal lethality."],"pmcid":["PMC11087113"],"pubmed_authors":["Shen L","He D","Li J","Wang B","Han L","Lin T","Zhao W","Lin X","Li Q","Cong J","Zhou Y","Zhao Z","Shen H","Zhou Z","Jia J","Huang S","Li Y","Xia J","Wu A","Dai G","Xiang X","Xiao D"],"additional_accession":[]},"is_claimable":false,"name":"Hepatocyte-specific METTL3 ablation by Alb-iCre mice (GPT), but not by Alb-Cre mice (JAX), resulted in acute liver failure (ALF) and postnatal lethality.","description":"<h4>Aim</h4>In 2019, to examine the functions of METTL3 in liver and underlying mechanisms, we generated mice with hepatocyte-specific METTL3 homozygous knockout (METTL3Δhep) by simultaneously crossing METTL3fl/fl mice with Alb-iCre mice (GPT) or Alb-Cre mice (JAX), respectively. In this study, we explored the potential reasons why hepatocyte-specific METTL3 homozygous disruption by Alb-iCre mice (GPT), but not by Alb-Cre mice (JAX), resulted in acute liver failure (ALF) and then postnatal lethality.<h4>Main methods</h4>Mice with hepatocyte-specific METTL3 knockout were generated by simultaneously crossing METTL3fl/fl mice with Alb-iCre mice (GPT; Strain No. T003814) purchased from the GemPharmatech Co., Ltd., (Nanjing, China) or with Alb-Cre mice (JAX; Strain No. 003574) obtained from The","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-06-02T11:24:45.363Z","creation":"2026-05-27T03:07:30.91Z"},"accession":"S-EPMC11087113","cross_references":{"pubmed":["38656880"],"doi":["10.18632/aging.205753"]}}