{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Smith EJ"],"funding":["Petplan Charitable Trust","Horserace Betting Levy Board"],"pagination":["1040-1059"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11087315"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(4)"],"pubmed_abstract":["Tissue fibrosis following tendon injury is a major clinical problem due to the increased risk of re-injury and limited treatment options; however, its mechanism remains unclear. Evidence suggests that insufficient resolution of inflammation contributes to fibrotic healing by disrupting tenocyte activity, with the NF-κB pathway being identified as a potential mediator. Equine embryonic stem cell (ESC) derived tenocytes may offer a potential cell-based therapy to improve tendon regeneration, but how they respond to an inflammatory environment is largely unknown. Our findings reveal for the first time that, unlike adult tenocytes, ESC-tenocytes are unaffected by IFN-γ, TNFα, and IL-1β stimulation; producing minimal changes to tendon-associated gene expression and generating 3-D collagen gel c"],"journal":["Stem cell reviews and reports"],"pubmed_title":["Equine Embryonic Stem Cell-Derived Tenocytes are Insensitive to a Combination of Inflammatory Cytokines and Have Distinct Molecular Responses Compared to Primary Tenocytes."],"pmcid":["PMC11087315"],"funding_grant_id":["S19-747- 786","S19-747– 786","VET/RS/257"],"pubmed_authors":["Guest DJ","Smith EJ","Beaumont RE","Dudhia J"],"additional_accession":[]},"is_claimable":false,"name":"Equine Embryonic Stem Cell-Derived Tenocytes are Insensitive to a Combination of Inflammatory Cytokines and Have Distinct Molecular Responses Compared to Primary Tenocytes.","description":"Tissue fibrosis following tendon injury is a major clinical problem due to the increased risk of re-injury and limited treatment options; however, its mechanism remains unclear. Evidence suggests that insufficient resolution of inflammation contributes to fibrotic healing by disrupting tenocyte activity, with the NF-κB pathway being identified as a potential mediator. Equine embryonic stem cell (ESC) derived tenocytes may offer a potential cell-based therapy to improve tendon regeneration, but how they respond to an inflammatory environment is largely unknown. Our findings reveal for the first time that, unlike adult tenocytes, ESC-tenocytes are unaffected by IFN-γ, TNFα, and IL-1β stimulation; producing minimal changes to tendon-associated gene expression and generating 3-D collagen gel c","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-07-15T07:57:53.77Z","creation":"2026-07-01T03:12:15.648Z"},"accession":"S-EPMC11087315","cross_references":{"pubmed":["38396222"],"doi":["10.1007/s12015-024-10693-8"]}}