{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang C"],"funding":["Peking University Medicine Sailing Program for Young Scholars’ Scientific & Technological Innovation","Peking University Medicine Sailing Program for Young Scholars' Scientific & Technological Innovation","Natural Science Foundation of China","Beijing Nova Program","Technology special fund of Hainan Province"],"pagination":["123"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11087383"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["73(7)"],"pubmed_abstract":["Adoptively transferred T cell receptor-engineered T cells are a promising cancer treatment strategy, and the identification of tumour-specific TCRs is essential. Previous studies reported that tumour-reactive T cells and TCRs could be isolated based on the expression of activation markers. However, since T cells with different cell states could not respond uniformly to activation but show a heterogeneous expression profile of activation and effector molecules, isolation of tumour-reactive T cells based on single activation or effector molecules could result in the absence of tumour-reactive T cells; thus, combinations of multiple activation and effector molecules could improve the efficiency of isolating tumour-specific TCRs. We enrolled two patients with lung adenocarcinoma and obtained t"],"journal":["Cancer immunology, immunotherapy : CII"],"pubmed_title":["Single-cell sequencing of tumour infiltrating T cells efficiently identifies tumour-specific T cell receptors based on the T cell activation score."],"pmcid":["PMC11087383"],"funding_grant_id":["20230484366","BMU2023YFJHPY011","ZDYF2024SHF2087","82373248"],"pubmed_authors":["Shen L","Yang W","Li S","Xiao Y","Lu Z","Teng X","Zhang C"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell sequencing of tumour infiltrating T cells efficiently identifies tumour-specific T cell receptors based on the T cell activation score.","description":"Adoptively transferred T cell receptor-engineered T cells are a promising cancer treatment strategy, and the identification of tumour-specific TCRs is essential. Previous studies reported that tumour-reactive T cells and TCRs could be isolated based on the expression of activation markers. However, since T cells with different cell states could not respond uniformly to activation but show a heterogeneous expression profile of activation and effector molecules, isolation of tumour-reactive T cells based on single activation or effector molecules could result in the absence of tumour-reactive T cells; thus, combinations of multiple activation and effector molecules could improve the efficiency of isolating tumour-specific TCRs. We enrolled two patients with lung adenocarcinoma and obtained t","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-04-16T03:19:33.669Z","creation":"2026-04-16T03:11:03.658Z"},"accession":"S-EPMC11087383","cross_references":{"pubmed":["38727812"],"doi":["10.1007/s00262-024-03710-9"]}}