biostudies-literatureZhang CScientific and Technological Research Project of Science and Technology Department of Henan ProvinceNational Natural Science Foundation of ChinaOpen Project Program of the Third Affiliated Hospital of Xinxiang Medical University571-586https://www.ebi.ac.uk/biostudies/studies/S-EPMC11087414biostudies-literatureUnknown21(4)<h4>Background</h4>Exosomes derived from breast cancer have been reported to play a role in promoting cell proliferation, migration, and angiogenesis, which has the potential to accelerate the healing process of diabetic wounds. The aim of this investigation was to examine the function of exosomes originating from 4T1 mouse breast carcinoma cells (TEXs) in the process of diabetic wound healing.<h4>Methods</h4>The assessment of primary mouse skin fibroblasts cell proliferation and migration was conducted through the utilization of CCK-8 and wound healing assays, while the tube formation of HUVECs was evaluated by tube formation assay. High-throughput sequencing, RT-qPCR and cell experiments were used to detect the roles of miR-126a-3p in HUVECs functions in vitro. The in vivo study employedTissue engineering and regenerative medicineExosomes Derived from Mouse Breast Carcinoma Cells Facilitate Diabetic Wound Healing.PMC11087414KFKTZD20210222210231018531600791KFKTYB202117232102311096Yang YXiao WNan WWang HHao YChen HZhang CLi LXu ZfalseExosomes Derived from Mouse Breast Carcinoma Cells Facilitate Diabetic Wound Healing.<h4>Background</h4>Exosomes derived from breast cancer have been reported to play a role in promoting cell proliferation, migration, and angiogenesis, which has the potential to accelerate the healing process of diabetic wounds. The aim of this investigation was to examine the function of exosomes originating from 4T1 mouse breast carcinoma cells (TEXs) in the process of diabetic wound healing.<h4>Methods</h4>The assessment of primary mouse skin fibroblasts cell proliferation and migration was conducted through the utilization of CCK-8 and wound healing assays, while the tube formation of HUVECs was evaluated by tube formation assay. High-throughput sequencing, RT-qPCR and cell experiments were used to detect the roles of miR-126a-3p in HUVECs functions in vitro. The in vivo study employed2024-01-01T00:00:00Z2024 Jun2026-06-01T18:02:13.5Z2025-04-04T00:21:47.163ZS-EPMC110874143847273210.1007/s13770-024-00629-1