{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Feng C"],"pubmed_abstract":["A-to-I mRNA editing in animals is mediated by ADARs, but the mechanism underlying sexual stage-specific A-to-I mRNA editing in fungi remains unknown. Here, we show that the eukaryotic tRNA-specific heterodimeric deaminase FgTad2-FgTad3 is responsible for A-to-I mRNA editing in Fusarium graminearum. This editing capacity relies on the interaction between FgTad3 and a sexual stage-specific protein called Ame1. Although Ame1 orthologs are widely distributed in fungi, the interaction originates in Sordariomycetes. We have identified key residues responsible for the FgTad3-Ame1 interaction. The expression and activity of FgTad2-FgTad3 are regulated through alternative promoters, alternative translation initiation, and post-translational modifications. Our study demonstrates that the FgTad2-FgTa"],"journal":["Nature communications"],"pagination":["3934"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11087585"],"repository":["biostudies-literature"],"pubmed_title":["Unveiling the A-to-I mRNA editing machinery and its regulation and evolution in fungi."],"pmcid":["PMC11087585"],"pubmed_authors":["Liu H","Xin K","Zou J","Xu JR","Xing X","Du Y","Kang Z","Feng C","Zhang R","Wang Q","Zhang Y","Huang W","Jiang C","Wang X","Xiu Q"],"additional_accession":[]},"is_claimable":false,"name":"Unveiling the A-to-I mRNA editing machinery and its regulation and evolution in fungi.","description":"A-to-I mRNA editing in animals is mediated by ADARs, but the mechanism underlying sexual stage-specific A-to-I mRNA editing in fungi remains unknown. Here, we show that the eukaryotic tRNA-specific heterodimeric deaminase FgTad2-FgTad3 is responsible for A-to-I mRNA editing in Fusarium graminearum. This editing capacity relies on the interaction between FgTad3 and a sexual stage-specific protein called Ame1. Although Ame1 orthologs are widely distributed in fungi, the interaction originates in Sordariomycetes. We have identified key residues responsible for the FgTad3-Ame1 interaction. The expression and activity of FgTad2-FgTad3 are regulated through alternative promoters, alternative translation initiation, and post-translational modifications. Our study demonstrates that the FgTad2-FgTa","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-01T20:16:33.422Z","creation":"2026-05-20T03:08:47.148Z"},"accession":"S-EPMC11087585","cross_references":{"pubmed":["38729938"],"doi":["10.1038/s41467-024-48336-8"]}}