{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Janowski J"],"funding":["U.S. Department of Energy","U.S. Department of Energy (DOE)","National Science Foundation (NSF)","DOD | USN | ONR | U.S. Naval Research Laboratory","DOD | USN | ONR | U.S. Naval Research Laboratory (NRL)","National Science Foundation"],"pagination":["e2321992121"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11087804"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["121(19)"],"pubmed_abstract":["Tertiary chirality describes the handedness of supramolecular assemblies and relies not only on the primary and secondary structures of the building blocks but also on topological driving forces that have been sparsely characterized. Helical biopolymers, especially DNA, have been extensively investigated as they possess intrinsic chirality that determines the optical, mechanical, and physical properties of the ensuing material. Here, we employ the DNA tensegrity triangle as a model system to locate the tipping points in chirality inversion at the tertiary level by X-ray diffraction. We engineer tensegrity triangle crystals with incremental rotational steps between immobile junctions from 3 to 28 base pairs (bp). We construct a mathematical model that accurately predicts and explains the mo"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Engineering tertiary chirality in helical biopolymers."],"pmcid":["PMC11087804"],"funding_grant_id":["CCF-2107393","DE-SC0007991","N000141912596","CCF-2107267"],"pubmed_authors":["Woloszyn K","Pham VAB","Rueb J","Janowski J","Saito M","Lu B","Vecchioni S","Zou Y","Mao C","Ohayon YP","Jonoska N","Perren L","Madnick J","Sha R","Erkalo B"],"additional_accession":[]},"is_claimable":false,"name":"Engineering tertiary chirality in helical biopolymers.","description":"Tertiary chirality describes the handedness of supramolecular assemblies and relies not only on the primary and secondary structures of the building blocks but also on topological driving forces that have been sparsely characterized. Helical biopolymers, especially DNA, have been extensively investigated as they possess intrinsic chirality that determines the optical, mechanical, and physical properties of the ensuing material. Here, we employ the DNA tensegrity triangle as a model system to locate the tipping points in chirality inversion at the tertiary level by X-ray diffraction. We engineer tensegrity triangle crystals with incremental rotational steps between immobile junctions from 3 to 28 base pairs (bp). We construct a mathematical model that accurately predicts and explains the mo","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-02T09:18:58.854Z","creation":"2025-04-04T23:32:27.061Z"},"accession":"S-EPMC11087804","cross_references":{"pubmed":["38684000"],"doi":["10.1073/pnas.2321992121"]}}