biostudies-literatureZhang T345 Talent Project of Shengjing Hospital of China Medical UniversityPeking University Clinical Medicine + X youth programNational Natural Science Foundation of ChinaNatural Science Major Project of the Anhui Provincial Department of EducationYoung Elite Scientists Sponsorship Program by China Association for Science and TechnologyBeijing Hospitals Authority Youth ProgrammeYouth Key Talents Program of Wannan Medical CollegeBeijing Chao-Yang Hospital Golden Seeds Foundation106https://www.ebi.ac.uk/biostudies/studies/S-EPMC11088014biostudies-literatureUnknown16(1)<h4>Background</h4>Previous studies on the associations between serum urate levels and neurodegenerative outcomes have yielded inconclusive results, and the causality remains unclear. This study aimed to investigate whether urate levels are associated with the risks of Alzheimer's disease and related dementias (ADRD), Parkinson's disease (PD), and neurodegenerative deaths.<h4>Methods</h4>This prospective study included 382,182 participants (45.7% men) from the UK Biobank cohort. Cox proportional hazards models were used to assess the associations between urate levels and risk of neurodegenerative outcomes. In the Mendelian randomization (MR) analysis, urate-related single-nucleotide polymorphisms were identified through a genome-wide association study. Both linear and non-linear MR approacAlzheimer's research & therapySerum urate levels and neurodegenerative outcomes: a prospective cohort study and mendelian randomization analysis of the UK Biobank.PMC11088014QML2023030182003456PKU2023LCXQ009WK202211M02942022AH051233CYJZ2021022020QNRC00182103811Yang HXia YJiang JZhang TShen ZLu YChen LAn YfalseSerum urate levels and neurodegenerative outcomes: a prospective cohort study and mendelian randomization analysis of the UK Biobank.<h4>Background</h4>Previous studies on the associations between serum urate levels and neurodegenerative outcomes have yielded inconclusive results, and the causality remains unclear. This study aimed to investigate whether urate levels are associated with the risks of Alzheimer's disease and related dementias (ADRD), Parkinson's disease (PD), and neurodegenerative deaths.<h4>Methods</h4>This prospective study included 382,182 participants (45.7% men) from the UK Biobank cohort. Cox proportional hazards models were used to assess the associations between urate levels and risk of neurodegenerative outcomes. In the Mendelian randomization (MR) analysis, urate-related single-nucleotide polymorphisms were identified through a genome-wide association study. Both linear and non-linear MR approac2024-01-01T00:00:00Z2024 May2026-06-01T05:35:07.616Z2026-04-08T09:35:57.539ZS-EPMC110880143873047410.1186/s13195-024-01476-x