{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao P"],"funding":["Key innovation Project and Science, Education and Industry Integration Innovation Pilot Project Qilu University of Technology (Shandong Academy of Sciences)","Key R&D Program of Shandong Province, China","Natural Science Foundation of Shandong Province","Jinan Talent Project for Universities","Education and Industry Integration Innovation Pilot Project Qilu University of Technology","Research Project for Talents Qilu University of Technology","Young Taishan Scholarship to Xuekui Xia","Education and Industry Integration Innovation Pilot Project Qilu University of Technology (Shandong Academy of Sciences)","Research Project for Talents Qilu University of Technology (Shandong Academy of Sciences)","Key R&D Program of Shandong Province, China","Key innovation Project and Science, Education and Industry Integration Innovation Pilot Project Qilu University of Technology"],"pagination":["332"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11088548"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["108(1)"],"pubmed_abstract":["Histone acetylation modifications in filamentous fungi play a crucial role in epigenetic gene regulation and are closely linked to the transcription of secondary metabolite (SM) biosynthetic gene clusters (BGCs). Histone deacetylases (HDACs) play a pivotal role in determining the extent of histone acetylation modifications and act as triggers for the expression activity of target BGCs. The genus Chaetomium is widely recognized as a rich source of novel and bioactive SMs. Deletion of a class I HDAC gene of Chaetomium olivaceum SD-80A, g7489, induces a substantial pleiotropic effect on the expression of SM BGCs. The C. olivaceum SD-80A ∆g7489 strain exhibited significant changes in morphology, sporulation ability, and secondary metabolic profile, resulting in the emergence of new compound pe"],"journal":["Applied microbiology and biotechnology"],"pubmed_title":["Activation of secondary metabolite gene clusters in Chaetomium olivaceum via the deletion of a histone deacetylase."],"pmcid":["PMC11088548"],"funding_grant_id":["tsqn202103100","2021GXRC062","2022JBZ01-06","2022PX051","ZR2022QC186","202228088","2023RCKY14","ZR2021QB173","ZR2021LSW022","2022SFGC0105","2022PX027"],"pubmed_authors":["Liu H","Yin X","Xia X","Qi J","Zhang L","Wang J","Meng Y","Zhang Q","Wang M","Zhang Y","Zhao P","Cao S","Lin J","Liu C"],"additional_accession":[]},"is_claimable":false,"name":"Activation of secondary metabolite gene clusters in Chaetomium olivaceum via the deletion of a histone deacetylase.","description":"Histone acetylation modifications in filamentous fungi play a crucial role in epigenetic gene regulation and are closely linked to the transcription of secondary metabolite (SM) biosynthetic gene clusters (BGCs). Histone deacetylases (HDACs) play a pivotal role in determining the extent of histone acetylation modifications and act as triggers for the expression activity of target BGCs. The genus Chaetomium is widely recognized as a rich source of novel and bioactive SMs. Deletion of a class I HDAC gene of Chaetomium olivaceum SD-80A, g7489, induces a substantial pleiotropic effect on the expression of SM BGCs. The C. olivaceum SD-80A ∆g7489 strain exhibited significant changes in morphology, sporulation ability, and secondary metabolic profile, resulting in the emergence of new compound pe","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-02T21:23:42.13Z","creation":"2026-04-20T03:14:22.307Z"},"accession":"S-EPMC11088548","cross_references":{"pubmed":["38734756"],"doi":["10.1007/s00253-024-13173-8"]}}