biostudies-literatureZhao PKey innovation Project and Science, Education and Industry Integration Innovation Pilot Project Qilu University of Technology (Shandong Academy of Sciences)Key R&D Program of Shandong Province, ChinaNatural Science Foundation of Shandong ProvinceJinan Talent Project for UniversitiesEducation and Industry Integration Innovation Pilot Project Qilu University of TechnologyResearch Project for Talents Qilu University of TechnologyYoung Taishan Scholarship to Xuekui XiaEducation and Industry Integration Innovation Pilot Project Qilu University of Technology (Shandong Academy of Sciences)Research Project for Talents Qilu University of Technology (Shandong Academy of Sciences)Key R&D Program of Shandong Province, ChinaKey innovation Project and Science, Education and Industry Integration Innovation Pilot Project Qilu University of Technology332https://www.ebi.ac.uk/biostudies/studies/S-EPMC11088548biostudies-literatureUnknown108(1)Histone acetylation modifications in filamentous fungi play a crucial role in epigenetic gene regulation and are closely linked to the transcription of secondary metabolite (SM) biosynthetic gene clusters (BGCs). Histone deacetylases (HDACs) play a pivotal role in determining the extent of histone acetylation modifications and act as triggers for the expression activity of target BGCs. The genus Chaetomium is widely recognized as a rich source of novel and bioactive SMs. Deletion of a class I HDAC gene of Chaetomium olivaceum SD-80A, g7489, induces a substantial pleiotropic effect on the expression of SM BGCs. The C. olivaceum SD-80A ∆g7489 strain exhibited significant changes in morphology, sporulation ability, and secondary metabolic profile, resulting in the emergence of new compound peApplied microbiology and biotechnologyActivation of secondary metabolite gene clusters in Chaetomium olivaceum via the deletion of a histone deacetylase.PMC11088548tsqn2021031002021GXRC0622022JBZ01-062022PX051ZR2022QC1862022280882023RCKY14ZR2021QB173ZR2021LSW0222022SFGC01052022PX027Liu HYin XXia XQi JZhang LWang JMeng YZhang QWang MZhang YZhao PCao SLin JLiu CfalseActivation of secondary metabolite gene clusters in Chaetomium olivaceum via the deletion of a histone deacetylase.Histone acetylation modifications in filamentous fungi play a crucial role in epigenetic gene regulation and are closely linked to the transcription of secondary metabolite (SM) biosynthetic gene clusters (BGCs). Histone deacetylases (HDACs) play a pivotal role in determining the extent of histone acetylation modifications and act as triggers for the expression activity of target BGCs. The genus Chaetomium is widely recognized as a rich source of novel and bioactive SMs. Deletion of a class I HDAC gene of Chaetomium olivaceum SD-80A, g7489, induces a substantial pleiotropic effect on the expression of SM BGCs. The C. olivaceum SD-80A ∆g7489 strain exhibited significant changes in morphology, sporulation ability, and secondary metabolic profile, resulting in the emergence of new compound pe2024-01-01T00:00:00Z2024 May2026-06-02T21:23:42.13Z2026-04-20T03:14:22.307ZS-EPMC110885483873475610.1007/s00253-024-13173-8