{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cates J"],"funding":["Intramural CDC HHS"],"pagination":["773-785"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11088931"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(11)"],"pubmed_abstract":["<h4>Background</h4>Adenovirus is a known cause of hepatitis in immunocompromised children, but not in immunocompetent children. In April, 2022, following multiple reports of hepatitis of unknown aetiology and adenovirus viraemia in immunocompetent children in the USA and UK, the US Centers for Disease Control and Prevention (CDC) and jurisdictional health departments initiated national surveillance of paediatric acute hepatitis of unknown aetiology. We aimed to describe the clinical and epidemiological characteristics of children identified with hepatitis of unknown aetiology between Oct 1, 2021, and Sept 30, 2022, in the USA and to compare characteristics of those who tested positive for adenovirus with those who tested negative.<h4>Methods</h4>In this national surveillance investigation "],"journal":["The Lancet. Child & adolescent health"],"pubmed_title":["Paediatric acute hepatitis of unknown aetiology: a national surveillance investigation in the USA during 2021 and 2022."],"pmcid":["PMC11088931"],"funding_grant_id":["CC999999"],"pubmed_authors":["Leitgeb B","Ingram LA","Antwi M","Gandhi A","Carter KK","Ayers-Millsap S","Cannon JL","Goebel R","St George K","Bankamp B","Taylor B","Saady D","Martines RB","Del Rosario MC","Burke RM","Tobin-D'Angelo M","Heaton T","Matthews J","Hanson J","Dao BL","Manchester C","Parashar UD","Ladisky M","Cebelinski E","Estetter LBC","Tapay D","McKeever ER","Stadelman AM","Do M","Langer C","Burakoff A","Wallace JL","Mallory K","Reed T","Thomas D","Freitas M","Bridges D","Cates J","Haupt T","Savella A","Phan Q","Berkley A","Kambhampati AK","Hepatitis of Unknown Etiology Group","Plipat N","Renton S","Leslie MT","Brousseau G","Cardona I","Derby MP","Salmanson AP","McLemore SD","Burnett E","Donahue M","Balachandran N","Jacoboski J","Kirking HL","Coughlin MM","Lamson DM","Wadford DA","Rodriguez MM","Gacek P","Anderson BJ","Balan D","Tate JE","Gastanaduy PA","Cubenas C","Peek-Bullock M","Lu X","Odegard A","Chhabra P","Stockman LJ","Morales C","Saathoff-Huber L","Baker JM","Gent A","Carlson K","Sugerman D","Boutwell C","Dodd A","Grilli G","Hand J","Schultz J","Rizzo KR","Solberg M","Freeman B","Julian D","Sepcic V","Kacka M","Vega EM","Kupferman N","Holzinger N","Hodge B","Silva-Flannery L","Abe KF","Wallace R","VanderBusch L","Dulski T","Dewart C","Lund H","Stone N","Almendares O","McAuley P","Reagan-Steiner S","Vinje J","Wayman A","Dessi D","Gehre M","Clayton J","Smith E","Panek A","Ghadge NM","Pan CY","Nguyen C","Byun Y","Bhatnagar J","Berns AL","Campbell C","Sietsema L","Popowich M","Sato AI"],"additional_accession":[]},"is_claimable":false,"name":"Paediatric acute hepatitis of unknown aetiology: a national surveillance investigation in the USA during 2021 and 2022.","description":"<h4>Background</h4>Adenovirus is a known cause of hepatitis in immunocompromised children, but not in immunocompetent children. In April, 2022, following multiple reports of hepatitis of unknown aetiology and adenovirus viraemia in immunocompetent children in the USA and UK, the US Centers for Disease Control and Prevention (CDC) and jurisdictional health departments initiated national surveillance of paediatric acute hepatitis of unknown aetiology. We aimed to describe the clinical and epidemiological characteristics of children identified with hepatitis of unknown aetiology between Oct 1, 2021, and Sept 30, 2022, in the USA and to compare characteristics of those who tested positive for adenovirus with those who tested negative.<h4>Methods</h4>In this national surveillance investigation ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2026-07-16T00:25:45.417Z","creation":"2025-04-06T15:23:59.98Z"},"accession":"S-EPMC11088931","cross_references":{"pubmed":["37774732"],"doi":["10.1016/S2352-4642(23)00192-X","10.1016/s2352-4642(23)00192-x"]}}