biostudies-literaturePei TFunds of Central Guidance for Local Scientific and Technological DevelopmentNatural Science Foundation of ChinaScience Research Project of Hebei Education Departmentthe Youth Top Talent Support Program of Hebei Province to ZY218https://www.ebi.ac.uk/biostudies/studies/S-EPMC11089763biostudies-literatureUnknown17(1)<h4>Background</h4>Epigenetic modifications of histones play important roles in the response of eukaryotic organisms to environmental stress. However, many histone acetyltransferases (HATs), which are responsible for histone acetylation, and their roles in mediating the tick response to cold stress have yet to be identified. In the present study, HATs were molecularly characterized and their associations with the cold response of the tick Haemaphysalis longicornis explored.<h4>Methods</h4>HATs were characterized by using polymerase chain reaction (PCR) based on published genome sequences, followed by multiple bioinformatic analyses. The differential expression of genes in H. longicornis under different cold treatment conditions was evaluated using reverse transcription quantitative PCR (RTParasites & vectorsMolecular characterization and induced changes of histone acetyltransferases in the tick Haemaphysalis longicornis in response to cold stress.PMC11089763236Z6503G32071510ZD20220082018-2023Bing ZYuan CNwanade CFLiu JGao ZZhang MMeng JYu ZLi LPei TfalseMolecular characterization and induced changes of histone acetyltransferases in the tick Haemaphysalis longicornis in response to cold stress.<h4>Background</h4>Epigenetic modifications of histones play important roles in the response of eukaryotic organisms to environmental stress. However, many histone acetyltransferases (HATs), which are responsible for histone acetylation, and their roles in mediating the tick response to cold stress have yet to be identified. In the present study, HATs were molecularly characterized and their associations with the cold response of the tick Haemaphysalis longicornis explored.<h4>Methods</h4>HATs were characterized by using polymerase chain reaction (PCR) based on published genome sequences, followed by multiple bioinformatic analyses. The differential expression of genes in H. longicornis under different cold treatment conditions was evaluated using reverse transcription quantitative PCR (RT2024-01-01T00:00:00Z2024 May2026-04-15T03:18:09.892Z2026-04-15T03:09:47.371ZS-EPMC110897633873591910.1186/s13071-024-06288-4