biostudies-literatureUnknown33(8)Bak YSTo investigate the molecular characteristics and antibiotic resistance of <i>Staphylococcus aureus</i> isolates from patients with diarrhea in Korea, 327 <i>S. aureus</i> strains were collected between 2007 and 2022. The presence of staphylococcal enterotoxin (SE) and toxic shock syndrome toxin-1 (TSST-1) genes in <i>S. aureus</i> isolates was determined by PCR. The highest expression of the TSST-1 gene was found in the GIMNO type (43.1% of GIMNO type). GIMNO type (Type I) refers to each staphylococcal enterotoxin (SE) gene gene (initials of genes): G = <i>seg</i>; I = <i>sei</i>; M = <i>selm</i>; N = <i>seln</i>; O = <i>selo</i>. Moreover, Type I isolates showed a significantly higher resistance to most antibiotics. A total of 195 GIMNO-type <i>S. aureus</i> strains were analyzed using multilocus sequence typing (MLST), and 18 unique sequence types (STs) were identified. The most frequent sequence type was ST72 (36.9%), followed by ST5 (22.1%) and ST30 (16.9%). Interestingly, ST72 strains showed a higher prevalence of MRSA than the other STs. In conclusion, our results were the first reported for <i>S. aureus</i> strains in Korea, which significantly expanded <i>S. aureus</i> genotype information for the surveillance of pathogenic <i>S. aureus</i> and may provide important epidemiological information to resolve several infectious diseases caused by <i>S. aureus</i>.<h4>Supplementary information</h4>The online version contains supplementary material available at 10.1007/s10068-023-01478-9.Food science and biotechnology1965-1974https://www.ebi.ac.uk/biostudies/studies/S-EPMC11091020biostudies-literatureMolecular characterization and antibiotic resistance of <i>Staphylococcus aureus</i> strains isolated from patients with diarrhea in Korea between the years 2007 and 2022.PMC11091020Park JYBak YSCho SHKim JBfalseMolecular characterization and antibiotic resistance of <i>Staphylococcus aureus</i> strains isolated from patients with diarrhea in Korea between the years 2007 and 2022.To investigate the molecular characteristics and antibiotic resistance of <i>Staphylococcus aureus</i> isolates from patients with diarrhea in Korea, 327 <i>S. aureus</i> strains were collected between 2007 and 2022. The presence of staphylococcal enterotoxin (SE) and toxic shock syndrome toxin-1 (TSST-1) genes in <i>S. aureus</i> isolates was determined by PCR. The highest expression of the TSST-1 gene was found in the GIMNO type (43.1% of GIMNO type). GIMNO type (Type I) refers to each staphylococcal enterotoxin (SE) gene gene (initials of genes): G = <i>seg</i>; I = <i>sei</i>; M = <i>selm</i>; N = <i>seln</i>; O = <i>selo</i>. Moreover, Type I isolates showed a significantly higher resistance to most antibiotics. A total of 195 GIMNO-type <i>S. aureus</i> strains were analyzed using multilocus sequence typing (MLST), and 18 unique sequence types (STs) were identified. The most frequent sequence type was ST72 (36.9%), followed by ST5 (22.1%) and ST30 (16.9%). Interestingly, ST72 strains showed a higher prevalence of MRSA than the other STs. In conclusion, our results were the first reported for <i>S. aureus</i> strains in Korea, which significantly expanded <i>S. aureus</i> genotype information for the surveillance of pathogenic <i>S. aureus</i> and may provide important epidemiological information to resolve several infectious diseases caused by <i>S. aureus</i>.<h4>Supplementary information</h4>The online version contains supplementary material available at 10.1007/s10068-023-01478-9.2024-01-01T00:00:00Z2024 Jun2025-04-04T02:35:57.508Z2025-04-04T02:35:57.508ZS-EPMC110910203875211810.1007/s10068-023-01478-9