biostudies-literatureSato SNihon University Research Grant for emerging infectious diseasesThe Japan Society for the Promotion of Science Grant-in-Aid for Young Scientists (B)The Japan Society for the Promotion of Science Grant-in-Aid for Young Scientists10941https://www.ebi.ac.uk/biostudies/studies/S-EPMC11091102biostudies-literatureUnknown14(1)Bartonella quintana, the causative agent of trench fever, is an intracellular bacterium that infects human erythrocytes and vascular endothelial cells. For many years, humans were considered the only natural hosts for B. quintana; however, it was recently discovered that wild Japanese macaques (Macaca fuscata) also serve as hosts for B. quintana. To elucidate the genetic characteristics of the B. quintana strain MF1-1 isolated from a Japanese macaque, we determined the complete genome sequence of the strain and compared it with those of strain Toulouse from a human and strain RM-11 from a rhesus macaque. General genomic features and orthologous gene cluster profiles are similar among the three strains, and strain MF1-1 is genetically closer to strain RM-11 than strain Toulouse based on theScientific reportsGenomic properties of a Bartonella quintana strain from Japanese macaque (Macaca fuscata) revealed by genome comparison with human and rhesus macaque strains.PMC11091102No. 268501882022-23 (Principal investigator: Satoshi Hayakawa)2022–23 (Principal investigator: Satoshi Hayakawa)Sato SNishioka EKabeya HMaruyama SfalseGenomic properties of a Bartonella quintana strain from Japanese macaque (Macaca fuscata) revealed by genome comparison with human and rhesus macaque strains.Bartonella quintana, the causative agent of trench fever, is an intracellular bacterium that infects human erythrocytes and vascular endothelial cells. For many years, humans were considered the only natural hosts for B. quintana; however, it was recently discovered that wild Japanese macaques (Macaca fuscata) also serve as hosts for B. quintana. To elucidate the genetic characteristics of the B. quintana strain MF1-1 isolated from a Japanese macaque, we determined the complete genome sequence of the strain and compared it with those of strain Toulouse from a human and strain RM-11 from a rhesus macaque. General genomic features and orthologous gene cluster profiles are similar among the three strains, and strain MF1-1 is genetically closer to strain RM-11 than strain Toulouse based on the2024-01-01T00:00:00Z2024 May2026-06-03T04:26:56.934Z2026-04-24T03:09:41.976ZS-EPMC110911023874080710.1038/s41598-024-61782-0