{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee C"],"funding":["Korea Electric Power Corporation","National Research Foundation of Korea (NRF)","National Cancer Center","National Cancer Center (NCC)","Ministry of Knowledge Economy | Korea Institute of Energy Technology Evaluation and Planning (KETEP)","National Research Foundation of Korea","Korea Electric Power Corporation (KEPCO)","Ministry of Knowledge Economy | Korea Institute of Energy Technology Evaluation and Planning"],"pagination":["4025"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11091103"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Intracellular membranes composing organelles of eukaryotes include membrane proteins playing crucial roles in physiological functions. However, a comprehensive understanding of the cellular responses triggered by intracellular membrane-focused oxidative stress remains elusive. Herein, we report an amphiphilic photocatalyst localised in intracellular membranes to damage membrane proteins oxidatively, resulting in non-canonical pyroptosis. Our developed photocatalysis generates hydroxyl radicals and hydrogen peroxides via water oxidation, which is accelerated under hypoxia. Single-molecule magnetic tweezers reveal that photocatalysis-induced oxidation markedly destabilised membrane protein folding. In cell environment, label-free quantification reveals that oxidative damage occurs primarily "],"journal":["Nature communications"],"pubmed_title":["Oxidative photocatalysis on membranes triggers non-canonical pyroptosis."],"pmcid":["PMC11091103"],"funding_grant_id":["R21XO02-8","20223030010240","2021R1A2C2009504","HA22C010100"],"pubmed_authors":["Wijesinghe WCB","Roh DH","Seo JK","Na S","Yang J","Park M","Hwang E","Lee C","Yoon G","Hughes SA","Lee CG","Kwon YH","Vince JE","Lee JK","Min D","Kwon TH"],"additional_accession":[]},"is_claimable":false,"name":"Oxidative photocatalysis on membranes triggers non-canonical pyroptosis.","description":"Intracellular membranes composing organelles of eukaryotes include membrane proteins playing crucial roles in physiological functions. However, a comprehensive understanding of the cellular responses triggered by intracellular membrane-focused oxidative stress remains elusive. Herein, we report an amphiphilic photocatalyst localised in intracellular membranes to damage membrane proteins oxidatively, resulting in non-canonical pyroptosis. Our developed photocatalysis generates hydroxyl radicals and hydrogen peroxides via water oxidation, which is accelerated under hypoxia. Single-molecule magnetic tweezers reveal that photocatalysis-induced oxidation markedly destabilised membrane protein folding. In cell environment, label-free quantification reveals that oxidative damage occurs primarily ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-05-29T10:25:23.293Z","creation":"2026-04-08T04:26:00.301Z"},"accession":"S-EPMC11091103","cross_references":{"pubmed":["38740804"],"doi":["10.1038/s41467-024-47634-5"]}}