biostudies-literatureLee ESHuman Frontier Science ProgramNTU | Lee Kong Chian School of Medicine, Nanyang Technological UniversityThomas and Stacey Siebel FoundationNational Healthcare GroupAdditional VenturesNational Health Innovation Centre SingaporeMinistry of Education - Singaporee202402598https://www.ebi.ac.uk/biostudies/studies/S-EPMC11091471biostudies-literatureUnknown7(7)Subclinical vascular impairment can be exacerbated in individuals who experience sustained inflammation after COVID-19 infection. Our study explores the prevalence and impact of autoantibodies on vascular dysfunction in healthy COVID-19 survivors, an area that remains inadequately investigated. Focusing on autoantibodies against the atypical chemokine receptor 1 (ACKR1), COVID-19 survivors demonstrated significantly elevated anti-ACKR1 autoantibodies, correlating with systemic cytokines, circulating damaged endothelial cells, and endothelial dysfunction. An independent cohort linked these autoantibodies to increased vascular disease outcomes during a median 6.7-yr follow-up. We analyzed a single-cell transcriptome atlas of endothelial cells from diverse mouse tissues, identifying enriched Life science allianceInflammatory risk contributes to post-COVID endothelial dysfunction through anti-ACKR1 autoantibody.PMC11091471RGY0069/2019980072Siebel InvestigatorStrategic Academic InitiativeCOVID19 CG008T2EP30122-0008ET1-2023-07Lye DCLoh KMDalan RCheung CWee HAng LTTay KYRenia LNguyen NLaw MCYoung BEFan BELee ESLee IRGoh LLChan MYLee KLChioh FWWazny VfalseInflammatory risk contributes to post-COVID endothelial dysfunction through anti-ACKR1 autoantibody.Subclinical vascular impairment can be exacerbated in individuals who experience sustained inflammation after COVID-19 infection. Our study explores the prevalence and impact of autoantibodies on vascular dysfunction in healthy COVID-19 survivors, an area that remains inadequately investigated. Focusing on autoantibodies against the atypical chemokine receptor 1 (ACKR1), COVID-19 survivors demonstrated significantly elevated anti-ACKR1 autoantibodies, correlating with systemic cytokines, circulating damaged endothelial cells, and endothelial dysfunction. An independent cohort linked these autoantibodies to increased vascular disease outcomes during a median 6.7-yr follow-up. We analyzed a single-cell transcriptome atlas of endothelial cells from diverse mouse tissues, identifying enriched 2024-01-01T00:00:00Z2024 Jul2026-06-01T18:50:58.014Z2026-05-19T03:07:10.036ZS-EPMC110914713874043210.26508/lsa.202402598