{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Massri AJ"],"funding":["NICHD NIH HHS"],"pubmed_abstract":["Altered regulatory interactions during development likely underlie a large fraction of phenotypic diversity within and between species, yet identifying specific evolutionary changes remains challenging. Analysis of single-cell developmental transcriptomes from multiple species provides a powerful framework for unbiased identification of evolutionary changes in developmental mechanisms. Here, we leverage a \"natural experiment\" in developmental evolution in sea urchins, where a major life history switch recently evolved in the lineage leading to <i>Heliocidaris erythrogramma</i>, precipitating extensive changes in early development. Comparative analyses of scRNA-seq developmental time courses from <i>H. erythrogramma</i> and <i>Lytechinus variegatus</i> (representing the derived and ancestra"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.04.30.591752"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11092583"],"repository":["biostudies-literature"],"pubmed_title":["Single-cell transcriptomics reveals evolutionary reconfiguration of embryonic cell fate specification in the sea urchin <i>Heliocidaris erythrogramma</i>."],"pmcid":["PMC11092583"],"funding_grant_id":["R01 HD014483","T32 HD040372"],"pubmed_authors":["Byrne M","McClay DR","Wray GA","Pipho K","Afanassiev A","Massri AJ","Berrio A","Greenstreet L","Schiebinger G"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell transcriptomics reveals evolutionary reconfiguration of embryonic cell fate specification in the sea urchin <i>Heliocidaris erythrogramma</i>.","description":"Altered regulatory interactions during development likely underlie a large fraction of phenotypic diversity within and between species, yet identifying specific evolutionary changes remains challenging. Analysis of single-cell developmental transcriptomes from multiple species provides a powerful framework for unbiased identification of evolutionary changes in developmental mechanisms. Here, we leverage a \"natural experiment\" in developmental evolution in sea urchins, where a major life history switch recently evolved in the lineage leading to <i>Heliocidaris erythrogramma</i>, precipitating extensive changes in early development. Comparative analyses of scRNA-seq developmental time courses from <i>H. erythrogramma</i> and <i>Lytechinus variegatus</i> (representing the derived and ancestra","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2025-08-12T03:04:48.268Z","creation":"2025-08-12T03:04:48.268Z"},"accession":"S-EPMC11092583","cross_references":{"pubmed":["38746376"],"doi":["10.1101/2024.04.30.591752"]}}