{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Warren R"],"funding":["NHLBI NIH HHS"],"pubmed_abstract":["Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease arising from the maladaptive differentiation of lung stem cells into bronchial epithelial cells rather than into alveolar type 1 (AT1) cells, which are responsible for gas exchange. Here, we report that healthy lungs maintain their stem cells through tonic Hippo and β-catenin signaling, which promote Yap/Taz degradation and allow for low level expression of the Wnt target gene <i>Myc</i>. Inactivation of upstream activators of the Hippo pathway in lung stem cells inhibits this tonic β-catenin signaling and <i>Myc</i> expression and promotes their Taz mediated differentiation into AT1 cells. Vice versa, increased Myc in collaboration with Yap promotes the differentiation of lung stem cells along the basal and myoepithelia"],"journal":["Research square"],"pagination":["rs.3.rs-4177351"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11092845"],"repository":["biostudies-literature"],"pubmed_title":["Cell competition drives bronchiolization and pulmonary fibrosis."],"pmcid":["PMC11092845"],"funding_grant_id":["R01 HL132156","T32 HL105355","R01 HL146461","R35 HL161169"],"pubmed_authors":["Stripp B","Warren R","Klinkhammer K","Lyu H","De Langhe SP","Yao C"],"additional_accession":[]},"is_claimable":false,"name":"Cell competition drives bronchiolization and pulmonary fibrosis.","description":"Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease arising from the maladaptive differentiation of lung stem cells into bronchial epithelial cells rather than into alveolar type 1 (AT1) cells, which are responsible for gas exchange. Here, we report that healthy lungs maintain their stem cells through tonic Hippo and β-catenin signaling, which promote Yap/Taz degradation and allow for low level expression of the Wnt target gene <i>Myc</i>. Inactivation of upstream activators of the Hippo pathway in lung stem cells inhibits this tonic β-catenin signaling and <i>Myc</i> expression and promotes their Taz mediated differentiation into AT1 cells. Vice versa, increased Myc in collaboration with Yap promotes the differentiation of lung stem cells along the basal and myoepithelia","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-07-02T03:11:38.059Z","creation":"2026-07-02T03:08:58.801Z"},"accession":"S-EPMC11092845","cross_references":{"pubmed":["38746309"],"doi":["10.21203/rs.3.rs-4177351/v1"]}}