biostudies-literatureUnknown22(8)Belardo C<h4>Background</h4>Integrins, important extracellular matrix (ECM) receptor proteins, are affected by inflammation and can participate in the maintenance of many painful conditions. Although they are ubiquitous and changeable across all cell types, the roles of these cell adhesion molecules in pathological pain have not been fully explored.<h4>Objective</h4>We evaluated the effects of the subcutaneous injection of lebecetin, a C-type lectin isolated from <i>Macrovipera lebetina</i> snake venom, previously reported to inhibit α5β1 and αv integrin activity, on different components of inflammation induced by the formalin administration in the hind paw of mice.<h4>Methods</h4>The formalin-induced nocifensive behavior, edema, and histopathological changes in the hind paw associated with cytokinCurrent neuropharmacology1391-1405https://www.ebi.ac.uk/biostudies/studies/S-EPMC11092918biostudies-literatureBiphasic Hormetic-like Effect of Lebecetin, a C-type Lectin of Snake Venom, on Formalin-induced Inflammation in Mice.PMC11092918Infantino RBonsale RPalazzo EScuteri DLuongo LIannotta MFerraraccio FMarrakchi NPerrone MGuida FBoccella SFusco AFerrara GJebali JManzo ISrairi-Abid NMaione SPanarese IBelardo CfalseBiphasic Hormetic-like Effect of Lebecetin, a C-type Lectin of Snake Venom, on Formalin-induced Inflammation in Mice.<h4>Background</h4>Integrins, important extracellular matrix (ECM) receptor proteins, are affected by inflammation and can participate in the maintenance of many painful conditions. Although they are ubiquitous and changeable across all cell types, the roles of these cell adhesion molecules in pathological pain have not been fully explored.<h4>Objective</h4>We evaluated the effects of the subcutaneous injection of lebecetin, a C-type lectin isolated from <i>Macrovipera lebetina</i> snake venom, previously reported to inhibit α5β1 and αv integrin activity, on different components of inflammation induced by the formalin administration in the hind paw of mice.<h4>Methods</h4>The formalin-induced nocifensive behavior, edema, and histopathological changes in the hind paw associated with cytokin2024-01-01T00:00:00Z20242025-04-19T02:24:26.352Z2024-11-21T06:50:03.132ZS-EPMC110929183807310610.2174/1570159X22999231207105743