biostudies-literatureFelipin KPConselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorCAPESe0012126https://www.ebi.ac.uk/biostudies/studies/S-EPMC11093365biostudies-literatureUnknown18(5)The parasite Leishmania (Viannia) braziliensis is widely distributed in Brazil and is one of the main species associated with human cases of different forms of tegumentary leishmaniasis (TL) such as cutaneous leishmaniasis (CL) and mucosal leishmaniasis (ML). The mechanisms underlying the pathogenesis of TL are still not fully understood, but it is known that factors related to the host and the parasite act in a synergistic and relevant way to direct the response to the infection. In the host, macrophages have a central connection with the parasite and play a fundamental role in the defense of the organism due to their ability to destroy intracellular parasites and present antigens. In the parasite, some intrinsic factors related to the species or even the strain analyzed are fundamental fPLoS neglected tropical diseasesTranscriptomics analysis highlights potential ways in human pathogenesis in Leishmania braziliensis infected with the viral endosymbiont LRV1.PMC11093365309627/2021-4311696/2021-0Doctoral fellowshipUniversal (428774/2016-4) and INCT-EpiAmo (465657/2014-1)Oliveira AERIkenohuchi YJDe Medeiros EHRTFerreira RGMZuliani JPSetubal SDSBoeno CNSerrath SNPimentel IFSilva MDSLopes JACantanhede LMFelipin KPRego CMAPaloschi MVSantana HMCupolillo EfalseTranscriptomics analysis highlights potential ways in human pathogenesis in Leishmania braziliensis infected with the viral endosymbiont LRV1.The parasite Leishmania (Viannia) braziliensis is widely distributed in Brazil and is one of the main species associated with human cases of different forms of tegumentary leishmaniasis (TL) such as cutaneous leishmaniasis (CL) and mucosal leishmaniasis (ML). The mechanisms underlying the pathogenesis of TL are still not fully understood, but it is known that factors related to the host and the parasite act in a synergistic and relevant way to direct the response to the infection. In the host, macrophages have a central connection with the parasite and play a fundamental role in the defense of the organism due to their ability to destroy intracellular parasites and present antigens. In the parasite, some intrinsic factors related to the species or even the strain analyzed are fundamental f2024-01-01T00:00:00Z2024 May2026-06-02T10:34:38.827Z2026-05-27T03:07:34.491ZS-EPMC110933653874366810.1371/journal.pntd.0012126