{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tannemann N"],"funding":["Bundesministerium für Bildung und Forschung","Heinz Nixdorf Stiftung","University of Duisburg-Essen","Deutsche Forschungsgemeinschaft","GE Imatron Inc., South San Francisco, CA and Sarstedt AG &amp; Co."],"pagination":["e0303357"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11093374"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(5)"],"pubmed_abstract":["Short telomeres are associated with cardiovascular disease (CVD). We aimed to investigate, if genetically determined telomere-length effects CVD-risk in the Heinz-Nixdorf-Recall study (HNRS) population. We selected 14 single-nucleotide polymorphisms (SNPs) associated with telomere-length (p<10-8) from the literature and after exclusion 9 SNPs were included in the analyses. Additionally, a genetic risk score (GRS) using these 9 SNPs was calculated. Incident CVD was defined as fatal and non-fatal myocardial infarction, stroke, and coronary death. We included 3874 HNRS participants with available genetic data and had no known history of CVD at baseline. Cox proportional-hazards regression was used to test the association between the SNPs/GRS and incident CVD-risk adjusting for common CVD risk"],"journal":["PloS one"],"pubmed_title":["Genetic polymorphisms affecting telomere length and their association with cardiovascular disease in the Heinz-Nixdorf-Recall study."],"pmcid":["PMC11093374"],"funding_grant_id":["ER 155/6-1","PE 2309/2-1"],"pubmed_authors":["Jockel KH","Erbel R","Pechlivanis S","Nothen MM","Tannemann N"],"additional_accession":[]},"is_claimable":false,"name":"Genetic polymorphisms affecting telomere length and their association with cardiovascular disease in the Heinz-Nixdorf-Recall study.","description":"Short telomeres are associated with cardiovascular disease (CVD). We aimed to investigate, if genetically determined telomere-length effects CVD-risk in the Heinz-Nixdorf-Recall study (HNRS) population. We selected 14 single-nucleotide polymorphisms (SNPs) associated with telomere-length (p<10-8) from the literature and after exclusion 9 SNPs were included in the analyses. Additionally, a genetic risk score (GRS) using these 9 SNPs was calculated. Incident CVD was defined as fatal and non-fatal myocardial infarction, stroke, and coronary death. We included 3874 HNRS participants with available genetic data and had no known history of CVD at baseline. Cox proportional-hazards regression was used to test the association between the SNPs/GRS and incident CVD-risk adjusting for common CVD risk","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-02T06:02:53.244Z","creation":"2026-04-15T03:09:53.372Z"},"accession":"S-EPMC11093374","cross_references":{"pubmed":["38743757"],"doi":["10.1371/journal.pone.0303357"]}}